Colorectal Neoplasms
|
0.500 |
GeneticVariation
|
group |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
Colorectal Neoplasms
|
0.500 |
CausalMutation
|
group |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
Colorectal Neoplasms
|
0.500 |
Biomarker
|
group |
CTD_human |
Highly Expressed Genes in Rapidly Proliferating Tumor Cells as New Targets for Colorectal Cancer Treatment.
|
25944804 |
2015 |
Colorectal Neoplasms
|
0.500 |
Biomarker
|
group |
CTD_human |
SMAD4--molecular gladiator of the TGF-beta signaling is trampled upon by mutational insufficiency in colorectal carcinoma of Kashmiri population: an analysis with relation to KRAS proto-oncogene.
|
20565773 |
2010 |
Colorectal Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Importantly, our analyses revealed that, while known CRC driver genes APC and SMAD4 were disrupted in both human colorectal tumors and tumors from ApcMin/+ mice, the questionable MCC gene was disrupted in human tumors but appeared to be intact in mouse tumors.
|
20707908 |
2010 |
Colorectal Neoplasms
|
0.500 |
AlteredExpression
|
group |
BEFREE |
Loss of Smad4 expression was observed in 42/304 (14%) colorectal tumors and was associated with reduced numbers of S100A8-positive (P = 0.03) but not S100A9-positive stromal cells (P = 0.26).
|
20622003 |
2010 |
Colorectal Neoplasms
|
0.500 |
AlteredExpression
|
group |
BEFREE |
We examined the immunohistochemical expression of Smad4 and frequency of KRAS mutation in primary colorectal tumors and in their corresponding metastatic tissues.
|
17390050 |
2007 |
Colorectal Neoplasms
|
0.500 |
AlteredExpression
|
group |
LHGDN |
We examined the immunohistochemical expression of Smad4 and frequency of KRAS mutation in primary colorectal tumors and in their corresponding metastatic tissues.
|
17390050 |
2007 |
Colorectal Neoplasms
|
0.500 |
CausalMutation
|
group |
CLINVAR |
Novel mutations in Smad proteins that inhibit signaling by the transforming growth factor beta in mammalian cells.
|
17994767 |
2007 |
Colorectal Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Mutation or deletion of Smad4 is found in about 50% of pancreatic tumors and in about 15% of colorectal tumors.
|
16135802 |
2005 |
Colorectal Neoplasms
|
0.500 |
GeneticVariation
|
group |
LHGDN |
Analysis of SMAD4/DPC4 gene alterations in multiploid colorectal carcinomas.
|
16082587 |
2005 |
Colorectal Neoplasms
|
0.500 |
Biomarker
|
group |
CTD_human |
SMAD4 levels and response to 5-fluorouracil in colorectal cancer.
|
16144935 |
2005 |
Colorectal Neoplasms
|
0.500 |
GeneticVariation
|
group |
LHGDN |
Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells.
|
14715079 |
2004 |
Colorectal Neoplasms
|
0.500 |
CausalMutation
|
group |
CLINVAR |
Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells.
|
14715079 |
2004 |
Colorectal Neoplasms
|
0.500 |
AlteredExpression
|
group |
LHGDN |
Status of the DPC4 tumor suppressor gene in sporadic colon adenocarcinoma of Croatian patients: identification of a novel somatic mutation.
|
15063137 |
2004 |
Colorectal Neoplasms
|
0.500 |
GeneticVariation
|
group |
LHGDN |
Infrequent mutation of the tumour-suppressor gene Smad4 in early-stage colorectal cancer.
|
12569386 |
2003 |
Colorectal Neoplasms
|
0.500 |
CausalMutation
|
group |
CLINVAR |
Role of Smad4 (DPC4) inactivation in human cancer.
|
12821112 |
2003 |
Colorectal Neoplasms
|
0.500 |
CausalMutation
|
group |
CLINVAR |
Transcriptional control by the TGF-beta/Smad signaling system.
|
10775259 |
2000 |
Colorectal Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
DCC and Smad4 aberrations have been previously identified in pancreatic and colorectal tumors.
|
10698524 |
2000 |
Colorectal Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
These results indicate that mutations in SMAD4 play a significant role in the malignant progression of colorectal tumors.
|
11197776 |
2000 |
Colorectal Neoplasms
|
0.500 |
CausalMutation
|
group |
CLINVAR |
Inactivation of both alleles of the DPC4/SMAD4 gene in advanced colorectal cancers: identification of seven novel somatic mutations in tumors from Japanese patients.
|
10479724 |
1999 |
Colorectal Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
These results indicate that mutations in DPC4 (SMAD4) play a significant role in the malignant progression of colorectal tumors.
|
9506519 |
1998 |
Colorectal Neoplasms
|
0.500 |
CausalMutation
|
group |
CLINVAR |
TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads.
|
9679244 |
1998 |
Colorectal Neoplasms
|
0.500 |
CausalMutation
|
group |
CLINVAR |
Somatic alterations of the DPC4 gene in human colorectal cancers in vivo.
|
8898652 |
1996 |