SMAD4, SMAD family member 4, 4089

N. diseases: 575; N. variants: 144
Disease: Liver neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.320 AlteredExpression group BEFREE TGF-β inhibition via overexpression of SMAD7 (or knockdown of SMAD2, SMAD3, or SMAD4) consistently reduced formation and growth of liver tumors in mice that expressed activated RAS plus shRNA against p53, or in mice that expressed activated RAS and TAZ. 28734833 2017
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.320 AlteredExpression group BEFREE Lentiviral-mediated Smad4 RNAi induced anti-proliferation by p16 up-regulation and apoptosis by caspase 3 down-regulation in hepatoma SMMC-7721 cells. 18949401 2008
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.320 Biomarker group RGD [Changes in TGF-beta1/Smads signaling pathway in rats with chemical hepatocarcinogenesis]. 18971187 2008
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.320 Biomarker group HPO