SMAD4, SMAD family member 4, 4089

N. diseases: 575; N. variants: 144
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.130 GeneticVariation disease BEFREE Using a genetic mouse model of melanoma in combination with in vitro analyses of melanoma cell lines, we found that conditional deletion of the downstream signaling molecule Smad4, which abrogates all canonical TGF-β signaling, indeed inhibits both tumor growth and metastasis. 31039140 2019
CUI: C0025202
Disease: melanoma
melanoma 		0.130 Biomarker disease BEFREE In conclusion, miR-146a functioned as an oncogene by directly targeting SMAD4 and it may be a novel diagnostic and therapeutic marker of MM. 29731876 2018
CUI: C0025202
Disease: melanoma
melanoma 		0.130 GeneticVariation disease BEFREE Accordingly, T-cell-specific deletion of Smad4 was sufficient to suppress the progression of melanoma. 24127404 2013
CUI: C0025202
Disease: melanoma
melanoma 		0.130 Biomarker disease HPO