SMAD6, SMAD family member 6, 4091

N. diseases: 93; N. variants: 26
Disease: Liver carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.020 Biomarker disease BEFREE Small interfering RNA knockdown of SMAD6 blocked the binding and infection of hepatoma cell lines and primary human hepatocytes by HCV, whereas SMAD6 overexpression increased HCV infection. 27693511 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.020 GeneticVariation disease BEFREE These results suggest that mutations of the Smad6 and Smad7 genes are not the main cause of the TGF-beta resistance in human HCC. 11408948 2001