|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.
|
18372901 |
2008 |
|
Colorectal Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genome-wide association studies (GWAS) have identified SMAD7 on 8q21 as being associated with colorectal cancer.
|
20124488 |
2010 |
|
Colorectal Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genome-wide association studies (GWAS) in colorectal cancer (CRC) identified five regions near transforming growth factor β-related genes BMP4, GREM1, CDH1, SMAD7 and RPHN2.
|
24753543 |
2014 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies a new SMAD7 risk variant associated with colorectal cancer risk in East Asians.
|
24448986 |
2014 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies a new SMAD7 risk variant associated with colorectal cancer risk in East Asians.
|
24448986 |
2014 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
|
26151821 |
2015 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of colorectal cancer in Hispanics.
|
27207650 |
2016 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.
|
29471430 |
2018 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
|
23266556 |
2013 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
|
23266556 |
2013 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
|
26965516 |
2016 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our data suggest that SMAD7 rs4939827 and CHI3L1 rs4950928 SNPs have no significant association with CRC.
|
26779637 |
2016 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In summary, this large-scale meta-analysis indicated that SMAD7 polymorphisms (rs4464148, rs4939827, and rs12953717) correlate with CRC.
|
28070019 |
2016 |
|
Colorectal Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
In this review, we summarize the available evidences about the role of Smad7 in both sporadic and colitis-associated CRC.
|
31052449 |
2019 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Intronic polymorphisms of the SMAD7 gene in association with colorectal cancer.
|
25640388 |
2015 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
|
24836286 |
2014 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
|
24836286 |
2014 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
|
30529582 |
2019 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.
|
19011631 |
2008 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Meta-analysis of new genome-wide association studies of colorectal cancer risk.
|
21761138 |
2012 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of new genome-wide association studies of colorectal cancer risk.
|
21761138 |
2012 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Moreover, we found cumulative effects of three genetic factors (rs7758229, rs6983267, and rs4939827 in SMAD7) and one environmental factor (alcohol drinking) which appear to increase CRC risk approximately twofold.
|
21242260 |
2011 |
|
Colorectal Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Mutational analysis of TGF-beta type II receptor, Smad2, Smad3, Smad4, Smad6 and Smad7 genes in colorectal cancer.
|
12866583 |
2003 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
|
29917119 |
2019 |
|
Colorectal Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our results, combined with previous studies, suggest that IL10, PSCA, IL1B, and SMAD7 are significantly correlated with CRC susceptibility in the Han Chinese population.
|
24557062 |
2015 |