MAF, MAF bZIP transcription factor, 4094

N. diseases: 71; N. variants: 28
Disease: Multiple Myeloma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.300 GeneticVariation disease BEFREE Immunohistochemistry for identification of CCND1, NSD2, and MAF gene rearrangements in plasma cell myeloma. 31218784 2019
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.300 GeneticVariation disease BEFREE A 60-year-old man with a history of plasma cell myeloma with IGH-MAF gene rearrangement and RAS/RAF mutations developed multiple soft tissue lesions one year following melphalan-based chemotherapy and autologous stem cell transplant. 29463311 2018
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.300 AlteredExpression disease BEFREE We now confirm that PIM2 is overexpressed in multiple myeloma (MM) patients, and within MM group it is overexpressed in the high-risk MF subset (activation of proto-oncogenes MAF/MAFB). 28008178 2017
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.300 Biomarker disease BEFREE Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation and myeloma cell apoptosis. 28933784 2017
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.300 Biomarker disease BEFREE These results define the role of MAF and GSK3 in the resistance of t(14;16) MM to PIs and identifies a novel mechanism by which MAF protein levels are regulated by PIs, which in turn confers resistance to PIs. 27793878 2016
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.300 AlteredExpression disease BEFREE Importantly, silencing of KDM3A, KLF2 or IRF4 both decreases MM cell adhesion to bone marrow stromal cells and reduces MM cell homing to the bone marrow, in association with decreased ITGB7 expression in MAF-translocated MM cell lines. 26728187 2016
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.300 GeneticVariation disease BEFREE Atypical IgM multiple myeloma with deletion of c-MAF. 25996654 2015
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.300 GeneticVariation disease BEFREE This novel TG mouse model of the human MM t(14;16)(q32;q23) chromosomal translocation should serve to provide new insight into the role of c-MAF in tumorigenesis. 21224354 2011
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.300 AlteredExpression disease BEFREE Dysregulated expression of Maf proteins (namely c-Maf, MafA and MafB) leads to multiple myeloma in humans and oncogenic transformation of chicken embryonic fibroblasts. 20718938 2010
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.300 AlteredExpression disease BEFREE Up-regulation of c-Maf protein occurs in a small subset of myelomas, in hairy cell leukemia, and in T- and NK-cell neoplasms. 19687312 2009
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.300 GeneticVariation disease BEFREE Besides their established role in human cancer--overexpression of the large Maf genes promotes the development of multiple myeloma--they can display tumour suppressor-like activity in specific cellular contexts, which is compatible with their physiological role in terminal differentiation. 19143053 2008
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.300 AlteredExpression disease BEFREE Maf proteins are overexpressed in about 50% of human multiple myelomas. 18042454 2007
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.300 Biomarker disease BEFREE Therefore, this atypical response element predicts a broader range of c-Maf target genes than previously appreciated and thus impacts its regulation of multiple myeloma as well as endothelial cell function and angiogenesis. 17897790 2007
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.300 Biomarker disease BEFREE ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma: ARK5 as a new molecular determinant of malignant multiple myeloma. 16044163 2005
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.300 AlteredExpression disease LHGDN C-MAF oncogene dysregulation in multiple myeloma: frequency and biological relevance. 14692531 2003
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.300 Biomarker disease BEFREE C-MAF oncogene dysregulation in multiple myeloma: frequency and biological relevance. 14692531 2003
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.300 GeneticVariation disease BEFREE In a continuing analysis of translocations in 21 MM lines, we show that the novel, karyotypically silent t(14;16)(q32.3;q23) translocation is present in 5 MM lines, with cloned breakpoints from 4 lines dispersed over an approximately 500-kb region centromeric to the c-maf proto-oncogene at 16q23. 9616139 1998
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.300 Biomarker disease MGD