|
Migraine with Aura
|
0.010 |
Biomarker
|
disease |
BEFREE |
Acid-sensing ion channel 1: a novel therapeutic target for migraine with aura.
|
23109150 |
2012 |
|
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
ASIC1 promotes differentiation of neuroblastoma by negatively regulating Notch signaling pathway.
|
28030818 |
2017 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
ASIC1 promotes differentiation of neuroblastoma by negatively regulating Notch signaling pathway.
|
28030818 |
2017 |
|
Childhood Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
ASIC1 promotes differentiation of neuroblastoma by negatively regulating Notch signaling pathway.
|
28030818 |
2017 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
ASIC1 knockdown extended the survival rate of animals and inhibited the tumor volume in the murine heterotopic xenograft model.
|
28111260 |
2017 |
|
Anxiety Disorders
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Although the ACCN2 gene may play a role in rodent fear conditioning, we could not detect association with genetic risk shared among human anxiety spectrum disorders.
|
18349698 |
2008 |
|
Anxiety
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Although the ACCN2 gene may play a role in rodent fear conditioning, we could not detect association with genetic risk shared among human anxiety spectrum disorders.
|
18349698 |
2008 |
|
Stomach Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Analysis of Polymorphism and Expression Profile of ASIC1 and IL-6 Genes in Patients with Gastric Cancer
|
30583668 |
2018 |
|
Malignant neoplasm of stomach
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Analysis of Polymorphism and Expression Profile of ASIC1 and IL-6 Genes in Patients with Gastric Cancer
|
30583668 |
2018 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Beneficial effect of mirtazapine on diabetes-induced hyperalgesia: involvement of TRPV1 and ASIC1 channels in the spinal cord and dorsal root ganglion.
|
30822229 |
2019 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
Beneficial effect of mirtazapine on diabetes-induced hyperalgesia: involvement of TRPV1 and ASIC1 channels in the spinal cord and dorsal root ganglion.
|
30822229 |
2019 |
|
Hyperalgesia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Beneficial effect of mirtazapine on diabetes-induced hyperalgesia: involvement of TRPV1 and ASIC1 channels in the spinal cord and dorsal root ganglion.
|
30822229 |
2019 |
|
Huntington Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Blocking acid-sensing ion channel 1 alleviates Huntington's disease pathology via an ubiquitin-proteasome system-dependent mechanism.
|
18658163 |
2008 |
|
Acute onset pain
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
DEAB activity appears to involve the opioid system, TRPM8, and ASIC receptors, clearly showing that the DEAB alleviates acute pain in mice and suggesting the involvement of the TRPM8 and ASIC receptors and the opioid system in acute pain relief.
|
29099043 |
2017 |
|
Stomach Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Down-regulation of ASIC1 suppressed gastric cancer via inhibiting autophagy.
|
28111260 |
2017 |
|
Malignant neoplasm of stomach
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Down-regulation of ASIC1 suppressed gastric cancer via inhibiting autophagy.
|
28111260 |
2017 |
|
Mechanical Allodynia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Effects of systemic inhibitors of acid-sensing ion channels 1 (ASIC1) against acute and chronic mechanical allodynia in a rodent model of migraine.
|
30079481 |
2018 |
|
Ischemia
|
0.010 |
Biomarker
|
phenotype |
LHGDN |
Endogenous arginine-phenylalanine-amide-related peptides alter steady-state desensitization of ASIC1a.
|
17984098 |
2008 |
|
Cerebrovascular accident
|
0.010 |
Biomarker
|
group |
LHGDN |
Endogenous arginine-phenylalanine-amide-related peptides alter steady-state desensitization of ASIC1a.
|
17984098 |
2008 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Experiments were performed in cultured FLS from wild-type (WT) and ASIC3-/- mice, ASIC1-/- mice, and people with rheumatoid arthritis.
|
24923411 |
2014 |
|
Brain Ischemia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis.
|
21307247 |
2011 |
|
Cerebral Ischemia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis.
|
21307247 |
2011 |
|
Lesion of brain
|
0.010 |
AlteredExpression
|
group |
BEFREE |
First, we assessed ASIC1 expression in chronic brain lesions from post-mortem of patients with progressive multiple sclerosis to identify the target process for neuroprotection.
|
23365093 |
2013 |
|
Progressive multiple sclerosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
First, we assessed ASIC1 expression in chronic brain lesions from post-mortem of patients with progressive multiple sclerosis to identify the target process for neuroprotection.
|
23365093 |
2013 |
|
Panic Disorder
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation at ACCN2 appears to be associated with PD and with amygdala phenotypes that have been linked to proneness to anxiety.
|
24529281 |
2014 |