ASIC1, acid sensing ion channel subunit 1, 41

N. diseases: 52; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia 		0.300 Biomarker disease CTD_human Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. 21307247 2011
CUI: C0917798
Disease: Cerebral Ischemia
Cerebral Ischemia 		0.300 Biomarker disease CTD_human Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. 21307247 2011
CUI: C0021368
Disease: Inflammation
Inflammation 		0.300 Biomarker phenotype CTD_human Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors. 11588175 2001
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.040 GeneticVariation disease BEFREE Inspired by rodent research, demonstrating that the acid-sensing ion channel 1a (ASIC1a) is critically involved in the behavioral fear response to carbon dioxide (CO<sub>2</sub>) exposure, variants in the human homologue gene amiloride-sensitive cation channel 2 (ACCN2) were shown to be associated with PD. 28121219 2017
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.040 Biomarker disease BEFREE The RS685012 Polymorphism of ACCN2, the Human Ortholog of Murine Acid-Sensing Ion Channel (ASIC1) Gene, is Highly Represented in Patients with Panic Disorder. 26589317 2016
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.040 GeneticVariation disease BEFREE Variants in RGS2 and ASIC1 genes were linked to panic disorder, with the latter also being implicated in SAD treatment response. 26575296 2016
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.040 GeneticVariation disease BEFREE Genetic variation at ACCN2 appears to be associated with PD and with amygdala phenotypes that have been linked to proneness to anxiety. 24529281 2014
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.030 Biomarker group BEFREE We previously reported that ASIC1 in pulmonary artery smooth muscle cells (PASMC) contribute to pulmonary vasoreactivity and vascular remodeling during the development of chronic hypoxia (CH)-induced pulmonary hypertension. 31169471 2019
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.030 AlteredExpression group BEFREE Repeated cross-fostering mouse pups to adoptive lactating females induces epigenetic modification and heightened mRNA-expression of the acid-sensing-ion-channel-1 gene, altered nociception, and hypersensitivity to 6% carbon dioxide air mixtures, a trait marker of specific human anxiety disorders such as, most clearly and prominently, panic disorder. 29968500 2018
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.030 Biomarker disease BEFREE Our study is the first report of attenuating the malignant phenotype of GC in vitro and in vivo by suppressing ASIC1a, and suggests a novel approach to study the relationship between ASICs and GC cell migration and invasion. 29584803 2018
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.030 AlteredExpression disease BEFREE Analysis of Polymorphism and Expression Profile of ASIC1 and IL-6 Genes in Patients with Gastric Cancer 30583668 2018
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.030 AlteredExpression disease BEFREE Down-regulation of ASIC1 suppressed gastric cancer via inhibiting autophagy. 28111260 2017
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.030 Biomarker group BEFREE Our findings support previously reported associations between ASIC1 and panic/anxiety, but not other genes previously associated with anxiety disorders. 25913301 2015
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.030 Biomarker group BEFREE Role of ASIC1 in the development of chronic hypoxia-induced pulmonary hypertension. 24186095 2014
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.030 Biomarker group BEFREE While blockade of ASIC1 through amiloride, a potassium sparing diuretic that is currently licensed for hypertension and congestive cardiac failure, showed neuroprotective and myeloprotective effects in experimental models of multiple sclerosis, this strategy remains untested in patients with multiple sclerosis. 23365093 2013
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.030 GeneticVariation group BEFREE Although the ACCN2 gene may play a role in rodent fear conditioning, we could not detect association with genetic risk shared among human anxiety spectrum disorders. 18349698 2008
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.020 AlteredExpression disease BEFREE Analysis of Polymorphism and Expression Profile of ASIC1 and IL-6 Genes in Patients with Gastric Cancer 30583668 2018
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.020 AlteredExpression disease BEFREE Down-regulation of ASIC1 suppressed gastric cancer via inhibiting autophagy. 28111260 2017
CUI: C0003467
Disease: Anxiety
Anxiety 		0.020 Biomarker disease BEFREE Our findings support previously reported associations between ASIC1 and panic/anxiety, but not other genes previously associated with anxiety disorders. 25913301 2015
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.020 Biomarker disease BEFREE Regulation of ASIC1 by Ca2+/calmodulin-dependent protein kinase II in human glioblastoma multiforme. 24100685 2013
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.020 Biomarker disease BEFREE However, it has not been determined whether Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates ASIC1 in glioblastoma multiforme (GBM). 24100685 2013
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.020 AlteredExpression disease BEFREE Using quantitative real time PCR, we have shown higher expression of ASIC1, alphaENaC, and gammaENaC in D54-MG human glioblastoma multiforme cells compared with primary human astrocytes. 19561078 2009
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.020 AlteredExpression disease BEFREE Using quantitative real time PCR, we have shown higher expression of ASIC1, alphaENaC, and gammaENaC in D54-MG human glioblastoma multiforme cells compared with primary human astrocytes. 19561078 2009
CUI: C0003467
Disease: Anxiety
Anxiety 		0.020 GeneticVariation disease BEFREE Although the ACCN2 gene may play a role in rodent fear conditioning, we could not detect association with genetic risk shared among human anxiety spectrum disorders. 18349698 2008
CUI: C0007682
Disease: CNS disorder
CNS disorder 		0.010 Biomarker group BEFREE The subtype ASIC1 is involved in various CNS diseases and therefore focusing on its specific functional properties will guide in drug design methods. 30124148 2019