ASIC1, acid sensing ion channel subunit 1, 41

N. diseases: 52; N. variants: 2
Disease: Panic Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.040 GeneticVariation disease BEFREE Inspired by rodent research, demonstrating that the acid-sensing ion channel 1a (ASIC1a) is critically involved in the behavioral fear response to carbon dioxide (CO<sub>2</sub>) exposure, variants in the human homologue gene amiloride-sensitive cation channel 2 (ACCN2) were shown to be associated with PD. 28121219 2017
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.040 Biomarker disease BEFREE The RS685012 Polymorphism of ACCN2, the Human Ortholog of Murine Acid-Sensing Ion Channel (ASIC1) Gene, is Highly Represented in Patients with Panic Disorder. 26589317 2016
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.040 GeneticVariation disease BEFREE Variants in RGS2 and ASIC1 genes were linked to panic disorder, with the latter also being implicated in SAD treatment response. 26575296 2016
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.040 GeneticVariation disease BEFREE Genetic variation at ACCN2 appears to be associated with PD and with amygdala phenotypes that have been linked to proneness to anxiety. 24529281 2014