MAOA, monoamine oxidase A, 4128

N. diseases: 300; N. variants: 15
Disease: Addictive Behavior ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0085281
Disease: Addictive Behavior
Addictive Behavior 		0.020 Biomarker phenotype BEFREE It is not surprising that the genes discovered so far act in a variety of ways: via altered metabolism of drug (the alcohol and nicotine metabolic gene variants), via altered function of a drug receptor (the nicotinic receptor, which may alter affinity for nicotine but as discussed may also alter circuitry of reward), and via general mechanisms of addiction (genes such as monoamine oxidase A and the serotonin transporter that modulate stress response, emotion, and behavioral control). 22640768 2012
CUI: C0085281
Disease: Addictive Behavior
Addictive Behavior 		0.020 AlteredExpression phenotype BEFREE Changes in MAO-A levels are associated with depression, trait aggression, and addiction. 22239616 2012