|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
These results suggest that a strong gender difference exists with respect to the modifying effect of MAO-B genotype on the smoking association with PD.
|
12428723 |
2002 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Recent studies suggest that polymorphism in monoamine oxidase B (MAOB) and catechol-O-methyltransferase (COMT) might influence the risk and treatment of PD.
|
15355491 |
2004 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
In conclusion, variants in FGF20 and MAOB show evidence of statistical interactions, which emphasizes the importance of considering them jointly in genetic analysis of PD and illustrates potential patterns of biological interaction contributing to PD risk.
|
18205889 |
2008 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our previous meta-analysis of PD genetic association studies, over a 30-year period yielded four genes (N-acetylcysteine 2, monoamine oxidase B, glutathione transferase, and mitochondrial tRNA), as their common variants were found to be associated with PD.
|
17868389 |
2007 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Using clinical data and DNA samples ascertained through the largest placebo-controlled clinical trial of the monoamine oxidase B inhibitor, rasagiline (ClinicalTrials.gov number, NCT00256204), we examined how polymorphisms in candidate genes associate with the clinical response to rasagiline in early Parkinson's disease.
|
27190009 |
2016 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association of a polymorphism in intron 13 of the monoamine oxidase B gene with Parkinson disease.
|
9129714 |
1997 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, variants in FGF20 and MAOB show evidence of statistical interactions, which emphasizes the importance of considering them jointly in genetic analysis of PD and illustrates potential patterns of biological interaction contributing to PD risk.
|
18205889 |
2008 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this meta-analysis provided evidence that the MAOB A644G polymorphism may contribute to PD development in Northern China.
|
27421021 |
2016 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The allele associated with PD in Caucasians was twice as frequent as in healthy Japanese, but the association of the allele of the MAO-B gene was not observed in Japanese patients with PD.
|
8825899 |
1995 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that a strong gender difference exists with respect to the modifying effect of MAO-B genotype on the smoking association with PD.
|
12428723 |
2002 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The COMT rs4680 and MAOB rs1799836 polymorphisms may increase susceptibility to PD risk among Japanese.
|
21781348 |
2011 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Selegiline, an irreversible inhibitor of monoamine oxidase (MAO)-type B, is widely prescribed for Parkinson's disease and, at higher doses, for major and atypical depression, whereby it is non-selectively inhibitory to both MAO-A and MAO-B activities.
|
30359642 |
2019 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Polymorphisms of catechol-0-methyltransferase (COMT), monoamine oxidase B (MAOB), N-acetyltransferase 2 (NAT2) and cytochrome P450 2D6 (CYP2D6) gene in patients with early onset of Parkinson's disease.
|
17270484 |
2007 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
MAO-B increases with age as does predisposition towards PD which has also been linked to increased oxidative stress.
|
15247489 |
2004 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association of Catechol-O-Methyltransferase and monoamine oxidase B gene polymorphisms with motor complications in parkinson's disease in a Chinese population.
|
25034874 |
2014 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The results of this meta-analysis suggest that people with the MAOB intron 13 A allele have an increased risk of PD in the Asian population, especially when combined with the COMT LL genotype.
|
26000819 |
2016 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
DNA sequence analysis of monoamine oxidase B gene coding and promoter regions in Parkinson's disease cases and unrelated controls.
|
14743364 |
2004 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We tested whether polymorphisms in the genes for catechol-O-methyltransferase (COMT), monoamine-oxidase B (MAO-B), and the dopamine transporter (DAT) influence dopamine uptake parameters in the striatum in vivo in asymptomatic volunteers and patients with PD as measured with (99)Tc-TRODAT-1.
|
12815660 |
2003 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Contrary to previous reports, our findings could not support the hypothesis that susceptibility to PD is associated with MAOA or MAOB polymorphism.
|
8929994 |
1996 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of the MAO B gene may modify the relationship between smoking and Parkinson's Disease (PD).
|
12815741 |
2003 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The MAOB (rs1799836) polymorphism predicts putaminal dopamine turnover in early PD with the MAOB<sup>TT</sup> allele linked to high enzyme activity leading to higher intrinsic dopamine turnover, which has been demonstrated to constitute a risk factor for motor complications.© 2018 The Authors.
|
30216543 |
2018 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The GT repeat in intron 2 of the MAOB gene is a powerful marker for PD in this large Australian cohort.
|
10091612 |
1999 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Rasagiline, a monoamine oxidase B inhibitor with neuroprotective potential in Parkinson's disease, has shown a disease-modifying effect in the SOD1-Gly93Ala low-expressing mouse model of amyotrophic lateral sclerosis, both alone and in combination with riluzole.
|
29934198 |
2018 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson's disease.
|
9596006 |
1998 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of catechol-0-methyltransferase (COMT), monoamine oxidase B (MAOB), N-acetyltransferase 2 (NAT2) and cytochrome P450 2D6 (CYP2D6) gene in patients with early onset of Parkinson's disease.
|
17270484 |
2007 |