|
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
An allelic association study of monoamine oxidase B in Parkinson's disease.
|
7695241 |
1995 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Here we have compared the frequency of haplotypes at the MAOA and MAOB loci on the X chromosome in 91 male patients with PD and 129 male controls.
|
7913737 |
1994 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The presence of MAO-B allele 1 is associated with a relative risk for PD of 2.03-fold (confidence interval, 1.44-2.61; p < 0.02).
|
8489207 |
1993 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The allele associated with PD in Caucasians was twice as frequent as in healthy Japanese, but the association of the allele of the MAO-B gene was not observed in Japanese patients with PD.
|
8825899 |
1995 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Contrary to previous reports, our findings could not support the hypothesis that susceptibility to PD is associated with MAOA or MAOB polymorphism.
|
8929994 |
1996 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association of a polymorphism in intron 13 of the monoamine oxidase B gene with Parkinson disease.
|
9129714 |
1997 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson's disease.
|
9596006 |
1998 |
|
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Monoamine oxidase (MAO), which exists in two forms (MAOA and MAOB), plays an important role in the oxidative metabolism of neurotransmitters such as dopamine, and has been implicated in the etiology of Parkinson's disease (PD).
|
9642149 |
1998 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The GT repeat in intron 2 of the MAOB gene is a powerful marker for PD in this large Australian cohort.
|
10091612 |
1999 |
|
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
An active role of monoamine oxidase B (MAO-B) in the pathogenesis of neurodegenerative disorders such as Parkinson's disease has been proposed as the enzyme is known to be a generator of free radicals which seem to be responsible for neuron oxidative damage.
|
10619718 |
1999 |
|
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Therefore the MAOB gene (MAOB; Xp15.21-4) is a candidate gene for Parkinson's disease (PD).
|
10701898 |
2000 |
|
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
When genotypes for DRD2 were considered in combination with genotypes for intron 13 of MAO-B, genotype combinations with high risk of Parkinson's disease were found; although the MAO-B/DRD2 interaction did not reach statistical significance after Bonferroni correction for multiple comparisons, these results are suggestive of a possible synergism between MAOB and DRD2 genes with respect to Parkinson's disease.
|
10990520 |
2000 |
|
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
R-(-)-Deprenyl (deprenyl, selegiline), a monoamine oxidase B (MAO-B) inhibitor, delays progression of Parkinson's disease.
|
11085911 |
2000 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
These results suggest that a strong gender difference exists with respect to the modifying effect of MAO-B genotype on the smoking association with PD.
|
12428723 |
2002 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that a strong gender difference exists with respect to the modifying effect of MAO-B genotype on the smoking association with PD.
|
12428723 |
2002 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We found statistically significant associations of PD with MAO-B polymorphisms in older patients and with a COMT polymorphism in younger subjects and in women.
|
12465073 |
2002 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We tested whether polymorphisms in the genes for catechol-O-methyltransferase (COMT), monoamine-oxidase B (MAO-B), and the dopamine transporter (DAT) influence dopamine uptake parameters in the striatum in vivo in asymptomatic volunteers and patients with PD as measured with (99)Tc-TRODAT-1.
|
12815660 |
2003 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of the MAO B gene may modify the relationship between smoking and Parkinson's Disease (PD).
|
12815741 |
2003 |
|
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
A number of other candidate gene polymorphisms including cytochrome P450 2D6, N-acetyltransferase 2, monoamine oxidase-B and glutathione-s-transferase M1 are implicated in sporadic and familial cases and may also play a minor role in the aetiology of Parkinson's disease.
|
14732367 |
2004 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
DNA sequence analysis of monoamine oxidase B gene coding and promoter regions in Parkinson's disease cases and unrelated controls.
|
14743364 |
2004 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
MAO-B increases with age as does predisposition towards PD which has also been linked to increased oxidative stress.
|
15247489 |
2004 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Recent studies suggest that polymorphism in monoamine oxidase B (MAOB) and catechol-O-methyltransferase (COMT) might influence the risk and treatment of PD.
|
15355491 |
2004 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Other studies reported that smoking modified the risk of PD due to polymorphisms in the MAO-B and nNOS genes.
|
15699372 |
2005 |
|
Parkinson Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Two distinct forms of enzyme, encoded by genes MAOA and MAOB located on the X chromosome, have been considered as possible factors in the pathogenesis of Parkinson disease (PD).
|
17044053 |
2006 |
|
Parkinson Disease
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Polymorphisms of catechol-0-methyltransferase (COMT), monoamine oxidase B (MAOB), N-acetyltransferase 2 (NAT2) and cytochrome P450 2D6 (CYP2D6) gene in patients with early onset of Parkinson's disease.
|
17270484 |
2007 |