MAP4, microtubule associated protein 4, 4134

N. diseases: 42; N. variants: 8
Disease: Malignant Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 PosttranslationalModification group BEFREE Knockdown of IKBKB/STK39 or EDN2/TBK1 enhanced paclitaxel sensitivity in two ovarian xenograft models.<b>Conclusions:</b> Sequential knockdown of dual kinases increased microtubule stability by decreasing p38-mediated phosphorylation of MAP4 and enhanced response to paclitaxel in ovarian cancer cell lines and xenografts, suggesting a strategy to improve primary therapy.<i>Clin Cancer Res; 24(20); 5072-84.©2018 AACR</i>. 30084832 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 Biomarker group BEFREE However, there is little information about the involvement of MAP4 in human cancer. 26876215 2016