|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
In addition to senile plaques, neurofibrillary tangles are characteristic of Alzheimer's disease (AD) pathology, suggesting a clear involvement of the microtubule-associated protein tau (MAPT) in AD.
|
17179995 |
2007 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
MAPT H1 associated with lower counts of NFTs in the middle frontal (p<0.001) and inferior parietal (p=0.005) cortices, and also with lower counts of senile plaques in the motor cortex (p=0.001).
|
22291217 |
2012 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
The deposit of two proteins in the brain characterizes Alzheimer's disease: deposits of beta-amyloid protein to form senile plaques and tau protein in neurofibrillary tangles.
|
12369957 |
2002 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
Alzheimer's disease (AD) is associated with amyloid plaques (Aβ) and hyperphosphorylated tau protein tangles in the brain.
|
28238167 |
2017 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
Isoform-specific differences have been identified in the binding of apoE to the microtubule-associated protein tau, which forms the paired helical filament and neurofibrillary tangles, and to amyloid beta peptide, a major component of the neuritic plaque.
|
7761390 |
1995 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
The pathophysiology of AD develops as a consequence of neurofibrillary tangle formation which consists of hyperphosphorylated microtubule associated tau protein and senile plaques of amyloid-β (Aβ) peptide in specific brain regions that result in synaptic loss and neuronal death.
|
29467648 |
2018 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
In this chapter, we assess the clinical and biochemical evidence implicating hypothermia as a risk factor for the development of AD and the impact of hypothermia on the two pathologic hallmarks of AD: accumulation of senile plaques of amyloid-beta and neurofibrillary tangles of aberrant hyperphosphorylated tau protein.
|
30459036 |
2018 |
|
Senile Plaques
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
We found that: (1) DA5-CH administration effectively improved working-memory and long-term spatial memory of 9-month-old AD mice in Y-maze and Morris water maze tests; (2) DA5-CH also reduced hippocampal amyloid senile plaques and phosphorylated tau protein levels; (3) DA5-CH basically reversed the deficits in hippocampal late-phase long-term potentiation; (4) DA5-CH up-regulated the levels of p-PI3K and p-AKT growth factor kinases and prevented excessive activation of p-GSK3β in the hippocampus of APP/PS1 mice.
|
29551659 |
2018 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
This disorder is characterized by the accumulation of beta amyloid plaques (Aβ) resulting from impaired amyloid precursor protein (APP) metabolism, together with the formation of neurofibrillary tangles and tau protein hyperphosphorylation.
|
31816853 |
2019 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
Neuropathological lesions, essential for the diagnosis of Alzheimer's disease (AD), such as senile-neuritic plaques (SP/NPs), neurofibrillary tangles (NFTs), the beta-amyloid load (A beta 4) and the load of PHF-tau did not increase with increased severity of cardiovascular disease in 126 clinically demented and 303 nondemented aged individuals.
|
10818513 |
2000 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
AD is characterized by deposition of senile plaques made of β-amyloid proteins (Aβ) and by hyperphosphorylation of tau proteins, which have been considered as the main drug targets up to now.
|
31274278 |
2019 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
This impairment is caused, at least partly, by the generation of two main AD hallmarks, namely the hyperphosphorylated tau protein comprising neurofibrillary tangles and senile plaques containing amyloid-β (Aβ) peptides.
|
28339396 |
2017 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
Reduced expression of brain-derived neurotrophic factor (BDNF) has a crucial role in the pathogenesis of Alzheimer's disease (AD), which is characterized with the formation of neuritic plaques consisting of amyloid-beta (Aβ) and neurofibrillary tangles composed of hyperphosphorylated tau protein.
|
27701410 |
2016 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the presence of extracellular amyloid plaques (senile plaques) and intracellular neurofibrillary tangles formed by hyperphosphorylated tau protein.
|
30767082 |
2019 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
The accumulation of amyloid-β-containing neuritic plaques and intracellular tau protein tangles are key histopathological hallmarks of Alzheimer's disease (AD).
|
23827971 |
2014 |
|
Senile Plaques
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A hallmark of this disease is the presence of aberrant deposits containing by the Aβ peptide (amyloid plaques) and the tau protein (neurofibrillary tangles) in the brains of affected individuals.
|
28652376 |
2017 |
|
Senile Plaques
|
0.200 |
PosttranslationalModification
|
disease |
BEFREE |
The two histopathological hallmarks of Alzheimer's disease (AD) are amyloid plaques containing multiple forms of amyloid beta (Aβ) and neurofibrillary tangles containing phosphorylated tau proteins.
|
24712999 |
2014 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
The accumulation of amyloid plaques (APs) composed of amyloid-beta peptide (Aβ) aggregates and neurofibrillary tangles (NFTs) composed of misfolded Tau proteins are the defining pathological markers of Alzheimer's disease (AD).
|
25561438 |
2016 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
In AD, β-amyloid (Aβ) and tau protein, capital agents for the senile plaques and intracellular neurofibrillary tangles, are called 'prionoids' indicating that proteins exhibit prion-like properties.
|
25212914 |
2014 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
Its pathogenesis is characterized by the aggregation of the amyloid-β (Aβ) protein in senile plaques and the hyperphosphorylated tau protein in neurofibrillary tangles in the brain.
|
30696107 |
2019 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
It is characterized by a progressive and irreversible loss of cognitive abilities and formation of senile plaques, composed mainly of amyloid β (Aβ), and neurofibrillary tangles (NFTs), composed of tau protein, in the hippocampus and cortex of afflicted humans.
|
29441009 |
2018 |
|
Senile Plaques
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Alzheimer's disease (AD) is a progressive senile dementia characterized by deposition of a 4 kDa peptide of 39-42 residues known as amyloid beta-peptide (Abeta) in the form of senile plaques and the microtubule associated protein tau as paired helical filaments.
|
15270198 |
2004 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
The primary pathological features of AD include senile plaques (SPs) and intracellular neurofibrillary tangles (NFTs), comprising aggregated amyloid β (Aβ) and hyperphosphorylated tau protein, respectively, in the hippocampus of AD patients.
|
29844403 |
2018 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
Histopathological hallmarks are represented by aggregates of beta-amyloid peptide (Aβ) in senile plaques and deposition of hyperphosphorylated tau protein in neurofibrillary tangles in the brain.
|
25927677 |
2015 |