|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
This disorder is characterized by the accumulation of beta amyloid plaques (Aβ) resulting from impaired amyloid precursor protein (APP) metabolism, together with the formation of neurofibrillary tangles and tau protein hyperphosphorylation.
|
31816853 |
2019 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
AD is characterized by deposition of senile plaques made of β-amyloid proteins (Aβ) and by hyperphosphorylation of tau proteins, which have been considered as the main drug targets up to now.
|
31274278 |
2019 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the presence of extracellular amyloid plaques (senile plaques) and intracellular neurofibrillary tangles formed by hyperphosphorylated tau protein.
|
30767082 |
2019 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
Its pathogenesis is characterized by the aggregation of the amyloid-β (Aβ) protein in senile plaques and the hyperphosphorylated tau protein in neurofibrillary tangles in the brain.
|
30696107 |
2019 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
Most of the research on Alzheimer's disease focuses on the correlation of its neuropathological changes in the neurofibrillary tangles caused by hyper-phosphorylated tau protein and β-amyloid plaques with respect to cognitive impairment.
|
31695992 |
2019 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
The formation of senile plaques and neurofibrillary tangles of the tau protein are the main pathological mechanism of Alzheimer's disease (AD).
|
29338678 |
2019 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
The accumulation of β-amyloid plaques and intracellular neurofibrillary tangles of hyperphosphorylated tau protein are two hallmarks of AD.
|
30964647 |
2019 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
The pathophysiology of AD develops as a consequence of neurofibrillary tangle formation which consists of hyperphosphorylated microtubule associated tau protein and senile plaques of amyloid-β (Aβ) peptide in specific brain regions that result in synaptic loss and neuronal death.
|
29467648 |
2018 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
In this chapter, we assess the clinical and biochemical evidence implicating hypothermia as a risk factor for the development of AD and the impact of hypothermia on the two pathologic hallmarks of AD: accumulation of senile plaques of amyloid-beta and neurofibrillary tangles of aberrant hyperphosphorylated tau protein.
|
30459036 |
2018 |
|
Senile Plaques
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
We found that: (1) DA5-CH administration effectively improved working-memory and long-term spatial memory of 9-month-old AD mice in Y-maze and Morris water maze tests; (2) DA5-CH also reduced hippocampal amyloid senile plaques and phosphorylated tau protein levels; (3) DA5-CH basically reversed the deficits in hippocampal late-phase long-term potentiation; (4) DA5-CH up-regulated the levels of p-PI3K and p-AKT growth factor kinases and prevented excessive activation of p-GSK3β in the hippocampus of APP/PS1 mice.
|
29551659 |
2018 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
It is characterized by a progressive and irreversible loss of cognitive abilities and formation of senile plaques, composed mainly of amyloid β (Aβ), and neurofibrillary tangles (NFTs), composed of tau protein, in the hippocampus and cortex of afflicted humans.
|
29441009 |
2018 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
The primary pathological features of AD include senile plaques (SPs) and intracellular neurofibrillary tangles (NFTs), comprising aggregated amyloid β (Aβ) and hyperphosphorylated tau protein, respectively, in the hippocampus of AD patients.
|
29844403 |
2018 |
|
Senile Plaques
|
0.200 |
PosttranslationalModification
|
disease |
BEFREE |
The major changes include the formation of senile plaques and neurofibrillary tangles primarily owing to the deposition of amyloid β plaques (Aβ) and hyper-phosphorylation of tau protein.
|
29183770 |
2018 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
The pathological hallmarks are extracellular deposits of amyloid plaques and intracellular neurofibrillary tangles of tau protein.
|
29274586 |
2018 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
Alzheimer's disease (AD), the most common chronic neurodegenerative disease, is pathologically characterized by the formation of neurofibrillary tangles because of hyperphosphorylation of tau protein and extracellular deposits of amyloid-β (Aβ) protein termed senile plaques.
|
29200096 |
2018 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
Pathologically, patients with AD are characterized by deposition of senile plaques (SPs), formed by β-amyloid (Aβ), and neurofibrillary tangles (NTFs) that consist of aggregated hyperphosphorylated tau protein.
|
30003951 |
2018 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
Alzheimer's disease (AD) is known to be caused by the accumulation of deformed beta amyloid and hyperphosphorylated tau proteins resulting into formation and aggregation of senile plaques and neurofibrillary tangles in the brain.
|
29377514 |
2018 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
Alzheimer's disease (AD) is associated with amyloid plaques (Aβ) and hyperphosphorylated tau protein tangles in the brain.
|
28238167 |
2017 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
This impairment is caused, at least partly, by the generation of two main AD hallmarks, namely the hyperphosphorylated tau protein comprising neurofibrillary tangles and senile plaques containing amyloid-β (Aβ) peptides.
|
28339396 |
2017 |
|
Senile Plaques
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A hallmark of this disease is the presence of aberrant deposits containing by the Aβ peptide (amyloid plaques) and the tau protein (neurofibrillary tangles) in the brains of affected individuals.
|
28652376 |
2017 |
|
Senile Plaques
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The senile plaques (SPs) and neurofibrillary tangles (NFTs) are the two major pathological hallmarks of AD, which are composed of β-amyloid protein and Tau protein.
|
28623460 |
2017 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
Reduced expression of brain-derived neurotrophic factor (BDNF) has a crucial role in the pathogenesis of Alzheimer's disease (AD), which is characterized with the formation of neuritic plaques consisting of amyloid-beta (Aβ) and neurofibrillary tangles composed of hyperphosphorylated tau protein.
|
27701410 |
2016 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
The accumulation of amyloid plaques (APs) composed of amyloid-beta peptide (Aβ) aggregates and neurofibrillary tangles (NFTs) composed of misfolded Tau proteins are the defining pathological markers of Alzheimer's disease (AD).
|
25561438 |
2016 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
It has now been ~ 30 years since the Alzheimer's disease (AD) research entered what may be termed the 'molecular era' that began with the identification of the amyloid β protein (Aβ) as the primary component of amyloid within senile plaques and cerebrovascular amyloid and the microtubule-associated protein tau as the primary component of neurofibrillary tangles in the AD brain.
|
27145445 |
2016 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
Histopathological hallmarks are represented by aggregates of beta-amyloid peptide (Aβ) in senile plaques and deposition of hyperphosphorylated tau protein in neurofibrillary tangles in the brain.
|
25927677 |
2015 |