MAPT, microtubule associated protein tau, 4137

N. diseases: 469; N. variants: 292
Disease: nervous system disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027765
Disease: nervous system disorder
nervous system disorder 		0.100 Biomarker group BEFREE Cdk5/p25 abnormally phosphorylates tau protein, and induces tau-associated neurofibrillary tangles in neurological disorders. 31073393 2019
CUI: C0027765
Disease: nervous system disorder
nervous system disorder 		0.100 Biomarker group BEFREE The association of MAPT (Tau) with various tauopathies and other neurological disorders has long been established. 30535461 2019
CUI: C0027765
Disease: nervous system disorder
nervous system disorder 		0.100 Biomarker group BEFREE Elevated levels of the cerebrospinal fluid (CSF) neuronal injury markers (neurofilament light chain [NF-L] and total tau protein [t-tau]) and of the astroglial marker glial fibrillary acidic protein (GFAP) are found in etiologically different neurological disorders affecting the peripheral and the central nervous system. 31087810 2019
CUI: C0027765
Disease: nervous system disorder
nervous system disorder 		0.100 Biomarker group BEFREE Aggregation of tau protein and spreading of tau aggregates are pivotal pathological processes in a range of neurological disorders. 30001207 2018
CUI: C0027765
Disease: nervous system disorder
nervous system disorder 		0.100 Biomarker group BEFREE Aggregated tau protein is associated with over 20 neurological disorders, which include Alzheimer's disease. 29359764 2018
CUI: C0027765
Disease: nervous system disorder
nervous system disorder 		0.100 Biomarker group BEFREE Interestingly, tau protein amounts were significantly affected in the cerebellar and hippocampal regions which coincidentally are the major brain regions affected in several neurological disorders. 29915575 2018
CUI: C0027765
Disease: nervous system disorder
nervous system disorder 		0.100 PosttranslationalModification group BEFREE The abnormal phosphorylation of tau protein is attributed to a wide gamut of neurological disorders known as tauopathies. 30149687 2018
CUI: C0027765
Disease: nervous system disorder
nervous system disorder 		0.100 Biomarker group BEFREE Microtubule-associated Tau proteins are the basic component of intraneuronal and glial inclusions observed in many neurological disorders, the so-called tauopathies. 15615637 2005
CUI: C0027765
Disease: nervous system disorder
nervous system disorder 		0.100 Biomarker group BEFREE Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) is a familial neurological disorder, characterized genetically by autosomal dominant inheritance, clinically by behavioral abnormalities and parkinsonism, and neuropathologically by tauopathy. 11159174 2001
CUI: C0027765
Disease: nervous system disorder
nervous system disorder 		0.100 Biomarker group BEFREE Through ultrastructual analyses, it has been determined that the tau protein in these lesions is filamentous and organized into paired-helical filaments, straight filaments, or ribbon-like filaments (Goedert et al., The Molecular and Genetic Basis of Neurological Disease (1997) 613). 11578871 2001
CUI: C0027765
Disease: nervous system disorder
nervous system disorder 		0.100 GeneticVariation group BEFREE The human tau gene, which promotes assembly of neuronal microtubules, has been associated with several rare neurologic diseases that clinically include parkinsonian features. 11710889 2001
CUI: C0027765
Disease: nervous system disorder
nervous system disorder 		0.100 Biomarker group BEFREE Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) is a familial neurological disorder exhibiting autosomal dominant inheritance. 11556544 2001
CUI: C0027765
Disease: nervous system disorder
nervous system disorder 		0.100 Biomarker group BEFREE To evaluate the usefulness of tau proteins as biological markers in the diagnosis of dementia of the Alzheimer type (DAT), we analyzed the concentration of tau proteins in 253 cerebrospinal fluid (CSF) samples from patients with or without neurological disorders. 10619631 1999