Plaque, Amyloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
This disorder is characterized by the accumulation of beta amyloid plaques (Aβ) resulting from impaired amyloid precursor protein (APP) metabolism, together with the formation of neurofibrillary tangles and tau protein hyperphosphorylation.
|
31816853 |
2019 |
Plaque, Amyloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Most of the research on Alzheimer's disease focuses on the correlation of its neuropathological changes in the neurofibrillary tangles caused by hyper-phosphorylated tau protein and β-amyloid plaques with respect to cognitive impairment.
|
31695992 |
2019 |
Plaque, Amyloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Approximately 65.6% and 36.1% of cases showed putaminal MAPT and amyloid deposits, respectively.
|
31206007 |
2019 |
Plaque, Amyloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
The accumulation of β-amyloid plaques and intracellular neurofibrillary tangles of hyperphosphorylated tau protein are two hallmarks of AD.
|
30964647 |
2019 |
Plaque, Amyloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
The pathological hallmarks are extracellular deposits of amyloid plaques and intracellular neurofibrillary tangles of tau protein.
|
29274586 |
2018 |
Plaque, Amyloid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A hallmark of this disease is the presence of aberrant deposits containing by the Aβ peptide (amyloid plaques) and the tau protein (neurofibrillary tangles) in the brains of affected individuals.
|
28652376 |
2017 |
Plaque, Amyloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Alzheimer's disease (AD) is associated with amyloid plaques (Aβ) and hyperphosphorylated tau protein tangles in the brain.
|
28238167 |
2017 |
Plaque, Amyloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
The accumulation of amyloid plaques (APs) composed of amyloid-beta peptide (Aβ) aggregates and neurofibrillary tangles (NFTs) composed of misfolded Tau proteins are the defining pathological markers of Alzheimer's disease (AD).
|
25561438 |
2016 |
Plaque, Amyloid
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
The two histopathological hallmarks of Alzheimer's disease (AD) are amyloid plaques containing multiple forms of amyloid beta (Aβ) and neurofibrillary tangles containing phosphorylated tau proteins.
|
24712999 |
2014 |
Plaque, Amyloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Biochemical modifications of tau proteins have been proposed to be among the earliest neurobiological changes in Alzheimer's disease (AD) and correlate better with cognitive symptoms than do beta-amyloid plaques.
|
18511295 |
2008 |
Plaque, Amyloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Neurodegenerative disorders referred to as tauopathies have cellular hyperphosphorylated tau protein aggregates in the absence of amyloid deposits.
|
10517507 |
1999 |