MAT1A, methionine adenosyltransferase 1A, 4143

N. diseases: 103; N. variants: 15
Disease: Chronic liver disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0341439
Disease: Chronic liver disease
Chronic liver disease 		0.020 GeneticVariation group BEFREE Mice deficient in methionine adenosyltransferase 1a (Mat1a KO) have chronic hepatic deficiency of S-adenosylmethionine (SAMe) and increased oxidative stress, and develop HCC. 18983843 2009
CUI: C0341439
Disease: Chronic liver disease
Chronic liver disease 		0.020 Biomarker group BEFREE Consequences of chronic hepatic SAMe depletion have been examined in the MAT1A knockout mouse model. 16054984 2005