The proteasome receptor DDI1 has been identified both in <i>Drosophila</i> photoreceptor neurons and in human neuroblastoma cells in culture as a direct substrate of UBE3A.
The proteasome receptor DDI1 has been identified both in <i>Drosophila</i> photoreceptor neurons and in human neuroblastoma cells in culture as a direct substrate of UBE3A.
The proteasome receptor DDI1 has been identified both in <i>Drosophila</i> photoreceptor neurons and in human neuroblastoma cells in culture as a direct substrate of UBE3A.
The novel observation that DDI1 is expressed in the developing mice brain, with a significant peak at E16.5, strongly suggests that DDI1 has biological functions not yet described that could be of relevance for Angelman syndrome clinical research.