Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The findings showed that miR-448 contributed to the progression of osteoarthritis by directly targeting matrilin-3.
|
29483929 |
2018 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
We investigated the presence of autoantibodies against the extracellular matrix proteins thrombospondin-4 (TSP-4), cartilage oligomeric matrix protein (COMP), C-type lectin domain family 3 member A (CLEC3A), collagen II, collagen VI, matrilin-3, and fibrillin-2 in the serum of osteoarthritis (OA) patients.
|
30001809 |
2018 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Furthermore, our results revealed miR-483-5p directly targeted to the cartilage matrix protein matrilin 3 (Matn3) and tissue inhibitor of metalloproteinase 2 (Timp2) to stimulate chondrocyte hypertrophy, extracellular matrix degradation, and cartilage angiogenesis, and it consequently initiated and accelerated the development of OA.
|
28139355 |
2017 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Therefore, we examined immunohistochemically the extracellular distribution of collagen II and the main perifibrillar adapter proteins-collagen IX, decorin, cartilage oligomeric matrix protein (COMP), and matrilin-3-in human samples of healthy (n=4) and OA (n=42) knee joint cartilage.
|
28846474 |
2017 |
Degenerative polyarthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The T303M polymorphism of the MATN3 gene, which was initially described as associated with hand osteoarthritis, may be more closely linked to trapeziometacarpal osteoarthritis than to digital osteoarthritis.
|
20971668 |
2011 |
Degenerative polyarthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We have previously shown that the mutations p.R116W and p.C299S, associated with MED and SEMD, respectively, cause retention of matrilin-3 within the endoplasmic reticulum of primary chondrocytes, while the mutation associated with osteoarthritis, p.T298M, does not hinder secretion.
|
20077500 |
2010 |
Degenerative polyarthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Matrilin-3 activates the expression of osteoarthritis-associated genes in primary human chondrocytes.
|
19840795 |
2009 |
Degenerative polyarthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
These activities of MATN3 suggest that its increased expression in osteoarthritis might contribute to the degeneration of articular cartilage.
|
18759284 |
2008 |
Degenerative polyarthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Mutations in matrilin-3 result in multiple epiphyseal dysplasia, which is characterized by delayed and irregular bone growth and early onset osteoarthritis.
|
17881354 |
2007 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
These associations suggest that the MATN3 region also determines susceptibility to spinal disc degeneration and CMC1 osteoarthritis.
|
16396979 |
2006 |
Degenerative polyarthritis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Genomewide scan for hand osteoarthritis: a novel mutation in matrilin-3.
|
12736871 |
2003 |
Degenerative polyarthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We conclude that matrilin-3 is an integral component of human articular cartilage matrix and that the enhanced expression of matrilin-3 in OA may be a cellular response to the modified microenvironment in the disease.
|
11950247 |
2002 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
CTD_human |
|
|
|