|
Pancreatic carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines.
|
16818649 |
2006 |
|
Malignant neoplasm of pancreas
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines.
|
16818649 |
2006 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
The presence of PIM3 increases hepatoblastoma tumorigenesis and tumor initiating cell phenotype and is associated with decreased patient survival.
|
30898394 |
2019 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Moreover, PIM3 knockdown was able to delay tumor growth and suppress lung metastasis in xenograft model.
|
30417983 |
2019 |
|
Liver carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Our results reveal a previously uncharacterized function of Ubenimex in mediating drug resistance in HCC, which suggests that Ubenimex may provide a new strategy to reverse MDR and improve HCC sensitivity to chemotherapeutic drugs via its effects on Pim-3.
|
29069816 |
2017 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Using knockdown studies, we showed that PIM1 contributes to melanoma cell proliferation and tumor growth in vivo; however, the presence of PIM2 and PIM3 could also influence the outcome.
|
27448973 |
2016 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Overall, these results reveal that miR-377 may have tumor growth suppression function by down-regulating Pim-3 kinase expression to inhibit both pancreatic tumor growth and migration, and induce cell apoptosis.
|
27638830 |
2016 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Overall, these results indicate that miR-33a functions as a tumor suppressor that downregulates Pim-3 kinase expression to inhibit both pancreatic tumor growth and gemcitabine resistance via the AKT/β-catenin pathway.
|
25971209 |
2015 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
A further analysis of HCC clinical specimens validated the connection between overexpression of LPAR6 and Pim-3, high proliferation rates, and poorer survival outcomes.
|
25589345 |
2015 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Collectively, the Pim-3 kinase emerges as being involved in accelerating human pancreatic cancer development and in promoting tumor neovascularization and subsequent tumor growth.
|
24789328 |
2014 |
|
Liver carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Immunotherapy for hepatoma using a dual-function vector with both immunostimulatory and pim-3-silencing effects.
|
24723452 |
2014 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
In the current study, we investigated the role of Pim-3 in promoting tumor growth and angiogenesis in an orthotopic nude mouse model of human pancreatic cancer.
|
23845873 |
2013 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Furthermore, we identified two oncogenes, NRAS and PIM3, as downstream targets of miR-124, one of the down-regulated miRNAs; and a tumor suppressor, CSMD1, as a downstream target of miR-10a and miR-10b, two of the up-regulated miRNAs.
|
22558405 |
2012 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the development of hepatocellular carcinoma is accelerated in mice expressing Pim-3 transgene selectively in the liver when these mice are treated with a hepatocarcinogen.
|
21981263 |
2012 |
|
Liver carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Knockdown of PIM-3 or CK2 by shRNA revealed that both kinases are important for hepatoma cell proliferation and survival.
|
21567083 |
2011 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
The development of hepatocellular carcinoma is accelerated in mice expressing the Pim-3 gene selectively in the liver only when these mice are treated with a hepatocarcinogen, indicating that Pim-3 can act as a promoter but not as an initiator.
|
21518143 |
2011 |
|
Liver carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Pim-3 transgenic mice developed HCC with a higher incidence (80%) and a heavier burden, together with enhanced intratumoral CD31-positive vascular areas, compared with that observed for wild-type mice.
|
20101231 |
2010 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
We previously observed that Pim-3, a member of the proto-oncogene Pim family that expresses serine/threonine kinase activity, was aberrantly expressed in human and mouse hepatomas but not in normal liver.
|
16818649 |
2006 |
|
Liver carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Moreover, Pim-3 protein was detected in human hepatocellular carcinoma tissues and cell lines but not in normal hepatocytes.
|
15540201 |
2005 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
LHGDN |
Furthermore, cell proliferation was attenuated and apoptosis was enhanced in human hepatoma cell lines by the ablation of Pim-3 gene with RNA interference.
|
15540201 |
2005 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
PIM3 was found to be expressed in a panel of human Ewing's family tumor cell lines.
|
12748291 |
2003 |
|
Carcinogenesis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
PIM3 expression plays a role in hepatoblastoma tumorigenesis.
|
30898394 |
2019 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
The PIM-3 kinase was the PIM family member most often associated with PC oncogenesis and was also the kinase inhibited the most by Ter among more than 600 kinases investigated.
|
31211245 |
2019 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
There is increasing evidence suggesting that the establishment of Pim-3 is involved in tumorigenesis.
|
26768612 |
2016 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Pim kinase-3(Pim-3), a member of serine/threonine protein kinases, has been implicated in multiple human cancers and involved in Myc-induced tumorigenesis.
|
25921139 |
2015 |