|
Malignant neoplasm of pancreas
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
There are reports indicating that overexpression of PIM3 is associated with the promotion of pancreatic cancer cell proliferation.
|
26238203 |
2015 |
|
Malignant neoplasm of pancreas
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The growth inhibitory effects of T26 were reversed by overexpression of Pim-3 cDNA in human pancreatic cancer cells, indicating that T26 acts primarily on Pim-3.
|
21981263 |
2012 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the development of hepatocellular carcinoma is accelerated in mice expressing Pim-3 transgene selectively in the liver when these mice are treated with a hepatocarcinogen.
|
21981263 |
2012 |
|
Liver carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Our results reveal a previously uncharacterized function of Ubenimex in mediating drug resistance in HCC, which suggests that Ubenimex may provide a new strategy to reverse MDR and improve HCC sensitivity to chemotherapeutic drugs via its effects on Pim-3.
|
29069816 |
2017 |
|
Liver carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Moreover, Pim-3 protein was detected in human hepatocellular carcinoma tissues and cell lines but not in normal hepatocytes.
|
15540201 |
2005 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
LHGDN |
Furthermore, cell proliferation was attenuated and apoptosis was enhanced in human hepatoma cell lines by the ablation of Pim-3 gene with RNA interference.
|
15540201 |
2005 |
|
Liver carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Knockdown of PIM-3 or CK2 by shRNA revealed that both kinases are important for hepatoma cell proliferation and survival.
|
21567083 |
2011 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
We previously observed that Pim-3, a member of the proto-oncogene Pim family that expresses serine/threonine kinase activity, was aberrantly expressed in human and mouse hepatomas but not in normal liver.
|
16818649 |
2006 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
A further analysis of HCC clinical specimens validated the connection between overexpression of LPAR6 and Pim-3, high proliferation rates, and poorer survival outcomes.
|
25589345 |
2015 |
|
Liver carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Immunotherapy for hepatoma using a dual-function vector with both immunostimulatory and pim-3-silencing effects.
|
24723452 |
2014 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
The development of hepatocellular carcinoma is accelerated in mice expressing the Pim-3 gene selectively in the liver only when these mice are treated with a hepatocarcinogen, indicating that Pim-3 can act as a promoter but not as an initiator.
|
21518143 |
2011 |
|
Liver carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Pim-3 transgenic mice developed HCC with a higher incidence (80%) and a heavier burden, together with enhanced intratumoral CD31-positive vascular areas, compared with that observed for wild-type mice.
|
20101231 |
2010 |
|
leukemia
|
0.050 |
Biomarker
|
disease |
BEFREE |
Similar to the other Pim kinases (Pim-1 and Pim-2), Pim-3 is involved in many cellular processes, including cell proliferation, survival, and protein synthesis.
|
25071334 |
2014 |
|
leukemia
|
0.050 |
Biomarker
|
disease |
BEFREE |
Pim-3 is a member of the Provirus integrating site Moloney murine leukemia virus (Pim) family, which belongs to the Ca(2+) /calmodulin-dependent protein kinase (CaMK) group and exhibits serine/threonine kinase activity.
|
21518143 |
2011 |
|
leukemia
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
PIM3 overexpression rescued the anti-proliferative effect observed with PIM3 knockdown.
|
30898394 |
2019 |
|
leukemia
|
0.050 |
Biomarker
|
disease |
BEFREE |
The provirus integrating site Moloney murine leukemia virus (PIM) family of serine/threonine protein kinases is composed of three members, PIM1, PIM2 and PIM3, which have been identified as oncoproteins in various malignancies.
|
27826617 |
2016 |
|
leukemia
|
0.050 |
Biomarker
|
disease |
BEFREE |
Pim-3 is a member of the provirus integration site for a moloney murine leukemia virus family of proteins that contributes to cell proliferation, survival, and chemotherapy resistance.
|
29167471 |
2017 |
|
Childhood Leukemia
|
0.050 |
Biomarker
|
disease |
BEFREE |
Pim-3 is a member of the Provirus integrating site Moloney murine leukemia virus (Pim) family, which belongs to the Ca(2+) /calmodulin-dependent protein kinase (CaMK) group and exhibits serine/threonine kinase activity.
|
21518143 |
2011 |
|
Childhood Leukemia
|
0.050 |
Biomarker
|
disease |
BEFREE |
The provirus integrating site Moloney murine leukemia virus (PIM) family of serine/threonine protein kinases is composed of three members, PIM1, PIM2 and PIM3, which have been identified as oncoproteins in various malignancies.
|
27826617 |
2016 |
|
Childhood Leukemia
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
PIM3 overexpression rescued the anti-proliferative effect observed with PIM3 knockdown.
|
30898394 |
2019 |
|
Childhood Leukemia
|
0.050 |
Biomarker
|
disease |
BEFREE |
Similar to the other Pim kinases (Pim-1 and Pim-2), Pim-3 is involved in many cellular processes, including cell proliferation, survival, and protein synthesis.
|
25071334 |
2014 |
|
Childhood Leukemia
|
0.050 |
Biomarker
|
disease |
BEFREE |
Pim-3 is a member of the provirus integration site for a moloney murine leukemia virus family of proteins that contributes to cell proliferation, survival, and chemotherapy resistance.
|
29167471 |
2017 |
|
Pancreatic Neoplasm
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Overall, these results indicate that miR-33a functions as a tumor suppressor that downregulates Pim-3 kinase expression to inhibit both pancreatic tumor growth and gemcitabine resistance via the AKT/β-catenin pathway.
|
25971209 |
2015 |
|
Pancreatic Neoplasm
|
0.040 |
Biomarker
|
disease |
BEFREE |
Moreover, Pim-3 is required for vasculogenesis of primary human pancreatic tumors in vivo and promotion of angiogenesis through the induction of VEGF expression.
|
23845873 |
2013 |
|
Pancreatic Neoplasm
|
0.040 |
AlteredExpression
|
disease |
LHGDN |
Essential contribution of Ets-1 to constitutive Pim-3 expression in human pancreatic cancer cells.
|
19154409 |
2009 |