|
Childhood Leukemia
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
PIM3 overexpression rescued the anti-proliferative effect observed with PIM3 knockdown.
|
30898394 |
2019 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
A further analysis of HCC clinical specimens validated the connection between overexpression of LPAR6 and Pim-3, high proliferation rates, and poorer survival outcomes.
|
25589345 |
2015 |
|
Burkitt Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Accordingly, lymphomas arising in Myc-transgenic mice and Burkitt lymphoma cell lines exhibit elevated levels of Pim-3.
|
21646687 |
2011 |
|
Adult Burkitt Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Accordingly, lymphomas arising in Myc-transgenic mice and Burkitt lymphoma cell lines exhibit elevated levels of Pim-3.
|
21646687 |
2011 |
|
Childhood Burkitt Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Accordingly, lymphomas arising in Myc-transgenic mice and Burkitt lymphoma cell lines exhibit elevated levels of Pim-3.
|
21646687 |
2011 |
|
Choriocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Aim of the study was to compare PIM1, PIM2 and PIM3 expression and potential cellular functions in human first and third trimester trophoblast cells, the immortalized first trimester extravillous trophoblast cell line HTR8/SVneo and the choriocarcinoma cell line JEG-3.
|
28729093 |
2017 |
|
Demyelinating Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Alpha-1 antitrypsin phenotypes in demyelinating disease: an association between demyelinating disease and the allele PiM3.
|
3878126 |
1985 |
|
Hepatocarcinogenesis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among the genes that were expressed differentially in the pre-malignant lesions, we focused on Pim-3, a member of a proto-oncogene Pim family, because its contribution to hepatocarcinogenesis remains unknown.
|
15540201 |
2005 |
|
Hematologic Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
BACKGROUND Pim-3 kinase is a highly homologous serine/threonine kinase that is overexpressed in hematological malignancies and solid tumors.
|
27826135 |
2016 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
Bufothionine exhibited anti-cancer activities in vitro and in vivo in GC via downregulating PIM3.
|
31260686 |
2019 |
|
Stomach Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Bufothionine exhibited anti-cancer activities in vitro and in vivo in GC via downregulating PIM3.
|
31260686 |
2019 |
|
Carcinogenesis
|
0.070 |
GeneticVariation
|
phenotype |
BEFREE |
Coexpression of a kinase-deficient PIM3 mutant attenuated EWS/FLI1-mediated NIH 3T3 tumorigenesis in immunodeficent mice.
|
12748291 |
2003 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Collectively, the Pim-3 kinase emerges as being involved in accelerating human pancreatic cancer development and in promoting tumor neovascularization and subsequent tumor growth.
|
24789328 |
2014 |
|
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Emerging evidence has shown that the PIM serine/threonine kinase family, including PIM1, PIM2 and PIM3, is associated with tumour progression towards metastasis.
|
29472550 |
2018 |
|
Neoplasm Metastasis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Emerging evidence has shown that the PIM serine/threonine kinase family, including PIM1, PIM2 and PIM3, is associated with tumour progression towards metastasis.
|
29472550 |
2018 |
|
Pancreatic Neoplasm
|
0.040 |
AlteredExpression
|
disease |
LHGDN |
Essential contribution of Ets-1 to constitutive Pim-3 expression in human pancreatic cancer cells.
|
19154409 |
2009 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Exposure of HNE-1 cells to docetaxel (IC25) alone had modest effect on cell proliferation and autophagy, and was not as effective as docetaxel treatment after knockdown of SSRP1, Ets-1 or Pim-3 on induction of the apoptosis and on inhibition of the invasion and clonogenicity.
|
27525970 |
2016 |
|
Solid Neoplasm
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Few studies have been conducted to define the role of Pim-3 in solid tumors, especially in prostate cancer.
|
27826135 |
2016 |
|
B-Cell Lymphomas
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Finally, we further demonstrated that miR-1235-3p could restrain the expression levels of TPT1, Pim-3, phosphate-Bcl-2-associated death promoter (p-BAD) and B-cell lymphoma-extra large (Bcl-XL) in A549/DDP cells, while the inhibition could be reversed by pcDNA3.1-TPT1 as well.
|
30805558 |
2018 |
|
Neoplasm Metastasis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Flotillin-2, fli-1, pim-3 and ezrin have previously been reported to be associated with tumor metastasis and progression.
|
16308470 |
2005 |
|
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Flotillin-2, fli-1, pim-3 and ezrin have previously been reported to be associated with tumor metastasis and progression.
|
16308470 |
2005 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
LHGDN |
Furthermore, cell proliferation was attenuated and apoptosis was enhanced in human hepatoma cell lines by the ablation of Pim-3 gene with RNA interference.
|
15540201 |
2005 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the development of hepatocellular carcinoma is accelerated in mice expressing Pim-3 transgene selectively in the liver when these mice are treated with a hepatocarcinogen.
|
21981263 |
2012 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Furthermore, we identified two oncogenes, NRAS and PIM3, as downstream targets of miR-124, one of the down-regulated miRNAs; and a tumor suppressor, CSMD1, as a downstream target of miR-10a and miR-10b, two of the up-regulated miRNAs.
|
22558405 |
2012 |
|
Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Here we describe three new targets of ZFP36 (PIM-1, PIM-3 and XIAP) and show by different approaches that its ectopic expression is capable of impairing glioblastoma cell lines viability and invasiveness by interfering with different transduction pathways.
|
22544323 |
2012 |