MBL2, mannose binding lectin 2, 4153

N. diseases: 563; N. variants: 21
Disease: Asthma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004096
Disease: Asthma
Asthma 		0.100 Biomarker disease BEFREE CLC/Gal-10 and MBP-1 may be useful biomarkers for differentiation of eosinophilic airway inflammation in asthma. 31157540 2019
CUI: C0004096
Disease: Asthma
Asthma 		0.100 GeneticVariation disease BEFREE The results indicated that MBL2 gene polymorphisms (codon 54 A/B, -550 H/L or -221 X/Y) may be not associated with the risk of asthma. 27590640 2016
CUI: C0004096
Disease: Asthma
Asthma 		0.100 GeneticVariation disease BEFREE The MBL2 codon 54 A/B polymorphism is significantly associated with asthma and its phenotypic traits as the wild (A/A) genotype confers a significant risk towards the disease in the studied North Indian population. 22674410 2012
CUI: C0004096
Disease: Asthma
Asthma 		0.100 GeneticVariation disease BEFREE To identify new markers of asthma and COPD to implement in clinical practice, we genotyped for common genetic variants in the cystic fibrosis transmembrane conductance regulator (CFTR), alpha(1)-antitrypsin, and mannose-binding lectin (MBL) genes, and measured baseline fibrinogen and C-reactive protein (CRP) concentrations in up to 9245 adults randomly selected from the Danish general population. 20298391 2009
CUI: C0004096
Disease: Asthma
Asthma 		0.100 AlteredExpression disease BEFREE An MBL level below the median concentration was a significant risk factor for infections (asthma status-adjusted odds ratio [OR], 2.5 [95% confidence interval {CI}, 1.4-4.5]). 18729778 2008
CUI: C0004096
Disease: Asthma
Asthma 		0.100 AlteredExpression disease BEFREE MBL levels and genotype have no significant relationship with serum IgE, pulmonary functions, and the severity of asthma. 17845414 2007
CUI: C0004096
Disease: Asthma
Asthma 		0.100 GeneticVariation disease BEFREE In contrast to previous studies, we found an association of MBL2 variants neither with the frequency of common respiratory childhood infections at any age nor with asthma or other atopy-related phenotypes. 17651383 2007
CUI: C0004096
Disease: Asthma
Asthma 		0.100 AlteredExpression disease BEFREE Elevated levels of mannan-binding lectin [corrected] (MBL) and eosinophilia in patients of bronchial asthma with allergic rhinitis and allergic bronchopulmonary aspergillosis associate with a novel intronic polymorphism in MBL. 16487239 2006
CUI: C0004096
Disease: Asthma
Asthma 		0.100 GeneticVariation disease BEFREE Polymorphisms at -550 and codon-54 (p < 0.0001 for both) but not at -221 (p = 0.534) of mbl2 were significantly associated with plasma MBL concentrations. mbl2 genotypes were not associated with asthma, atopy, sensitization to individual aeroallergens or spirometric variable. 17014624 2006
CUI: C0004096
Disease: Asthma
Asthma 		0.100 Biomarker disease BEFREE However, as MBL is a complement component participating in immune defence against microbes, and as in the pathogenesis of non-atopic asthma infectious agents are probably involved, the gene-environment interactions between MBL and infections should be assessed further with regard to asthma. 16178865 2005
CUI: C0004096
Disease: Asthma
Asthma 		0.100 AlteredExpression disease LHGDN Mannose-binding lectin levels in children with asthma. 15853952 2005
CUI: C0004096
Disease: Asthma
Asthma 		0.100 GeneticVariation disease BEFREE Infected children with variant MBL alleles were found to have a higher risk of asthma development than infected children with normal MBL genotype. 14564351 2003