MBL2, mannose binding lectin 2, 4153

N. diseases: 563; N. variants: 21
Disease: Cytomegalovirus Infections ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010823
Disease: Cytomegalovirus Infections
Cytomegalovirus Infections 		0.070 AlteredExpression group BEFREE Low MBL levels were associated with CMV infection in Chinese individuals, a finding that was not replicated in Caucasians. 27586547 2016
CUI: C0010823
Disease: Cytomegalovirus Infections
Cytomegalovirus Infections 		0.070 GeneticVariation group BEFREE Collaborative studies suggested that both activating and inhibitory KIR and functionally relevant MBL2 haplotypes are important factors for control of CMV infection in the elderly and therefore for chronic low-grade inflammation. 23302099 2013
CUI: C0010823
Disease: Cytomegalovirus Infections
Cytomegalovirus Infections 		0.070 Biomarker group BEFREE Human mannose-binding lectin inhibits human cytomegalovirus infection in human embryonic pulmonary fibroblast. 22779691 2012
CUI: C0010823
Disease: Cytomegalovirus Infections
Cytomegalovirus Infections 		0.070 AlteredExpression group BEFREE Serum MBL levels of patients with active CMV infection were significantly lower than those of controls (p<0.05). 22444663 2012
CUI: C0010823
Disease: Cytomegalovirus Infections
Cytomegalovirus Infections 		0.070 GeneticVariation group BEFREE MBL2 and FCN2 risk alleles of donor liver and recipient constitute independent risk factors for CMV infection after OLT. 21334396 2011
CUI: C0010823
Disease: Cytomegalovirus Infections
Cytomegalovirus Infections 		0.070 Biomarker group BEFREE These data suggest MBL does not have a major influence on susceptibility to prenatal or perinatal CMV infections. 21722964 2011
CUI: C0010823
Disease: Cytomegalovirus Infections
Cytomegalovirus Infections 		0.070 Biomarker group BEFREE Thus we can speculate that as an acute response protein and a pattern-recognition molecule of the innate immune system, MBL may play a role in protecting against HCMV infection in children, and MBL gene mutations may be a significant risk factor for the development of infantile HCMV infection. 20712489 2010