Schizophrenia
|
0.580 |
Biomarker
|
disease |
BEFREE |
Approximately 82% electrophoretically homogeneous SCZ IgGs purified using several affinity sorbents including Sepharose with immobilized MBP hydrolyze specifically only MBP but not many other tested proteins.
|
30112774 |
2019 |
Schizophrenia
|
0.580 |
Biomarker
|
disease |
RGD |
Myelination deficit in a phencyclidine-induced neurodevelopmental model of schizophrenia.
|
22750584 |
2012 |
Schizophrenia
|
0.580 |
AlteredExpression
|
disease |
LHGDN |
Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis.
|
19034380 |
2009 |
Schizophrenia
|
0.580 |
AlteredExpression
|
disease |
BEFREE |
In addition we performed an expression analysis of golli-MBP mRNA in post-mortem dorsolateral prefrontal cortex samples of schizophrenia patients, and matched controls.
|
19154657 |
2009 |
Schizophrenia
|
0.580 |
Biomarker
|
disease |
PSYGENET |
Myelin basic protein and 2', 3'-cyclic nucleotide 3'-phosphodiesterase were also significantly decreased in the mouse model of SZ.
|
24788877 |
2014 |
Schizophrenia
|
0.580 |
AlteredExpression
|
disease |
BEFREE |
These findings indicate that altered expression levels of hnRNP C in the brain of patients with schizophrenia could be involved in the pathophysiology of this disease through alteration of the QKI isoform and myelin basic protein expression.
|
21684615 |
2011 |
Schizophrenia
|
0.580 |
AlteredExpression
|
disease |
BEFREE |
Western blot analysis was used to compare protein levels of myelin basic protein, neurofilament heavy, autophagosome marker LC3, and microtubule marker α-tubulin in post-mortem human CB, CC, and AF in schizophrenia subjects (SZ) and matched normal controls (NC).
|
30735241 |
2019 |
Schizophrenia
|
0.580 |
AlteredExpression
|
disease |
LHGDN |
These included alterations previously implicated in schizophrenia, such as oligodendrocyte-related proteins (myelin basic protein and transferrin), as well as malate dehydrogenase, aconitase, ATP synthase subunits and cytoskeleton-related proteins.
|
19110265 |
2009 |
Schizophrenia
|
0.580 |
Biomarker
|
disease |
PSYGENET |
Reduced MBP mRNA in schizophrenia replicates findings in other brain regions and is consistent with oligodendrocyte involvement in the disorder.
|
22675524 |
2012 |
Schizophrenia
|
0.580 |
Biomarker
|
disease |
PSYGENET |
In addition we performed an expression analysis of golli-MBP mRNA in post-mortem dorsolateral prefrontal cortex samples of schizophrenia patients, and matched controls.
|
19154657 |
2009 |
Schizophrenia
|
0.580 |
AlteredExpression
|
disease |
BEFREE |
Reduced MBP mRNA in schizophrenia replicates findings in other brain regions and is consistent with oligodendrocyte involvement in the disorder.
|
22675524 |
2012 |
Schizophrenia
|
0.580 |
Biomarker
|
disease |
PSYGENET |
Correlation and factor analyses revealed that mRNA levels for genes that did exhibit differential expression in schizophrenia (MAG, CNP, SOX10, CLDN11, and PMP2), as opposed to those that did not (MOBP and MBP), loaded on separate factors.
|
16213148 |
2006 |
Schizophrenia
|
0.580 |
AlteredExpression
|
disease |
BEFREE |
Correlation and factor analyses revealed that mRNA levels for genes that did exhibit differential expression in schizophrenia (MAG, CNP, SOX10, CLDN11, and PMP2), as opposed to those that did not (MOBP and MBP), loaded on separate factors.
|
16213148 |
2006 |