MC4R, melanocortin 4 receptor, 4160

N. diseases: 149; N. variants: 58
Disease: Cachexia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006625
Disease: Cachexia
Cachexia 		0.040 Biomarker phenotype BEFREE These data clearly demonstrate the potential of small molecule MC4-R antagonists in the treatment of cachexia and underscore the importance of melanocortin signaling in the development of this metabolic disorder. 15774557 2005
CUI: C0006625
Disease: Cachexia
Cachexia 		0.040 Biomarker phenotype BEFREE We tested the hypothesis that uremia-associated cachexia is caused by leptin signaling through the hypothalamic melanocortin receptor 4 (MC4-R). 15931394 2005
CUI: C0006625
Disease: Cachexia
Cachexia 		0.040 Biomarker phenotype BEFREE Recent studies have demonstrated that melanocortin-4 receptor (MC4R) antagonists can prevent weight loss in tumor-bearing mice, which indicates clinical usage for the treatment of cachexia. 15615531 2004
CUI: C0006625
Disease: Cachexia
Cachexia 		0.040 GeneticVariation phenotype BEFREE In this paper, we provide evidence that in both acute and chronic disease models, blockade of the MC4-R results in a dramatic attenuation of cachexia. 12851324 2003