|
Hypertensive disease
|
0.200 |
Biomarker
|
group |
BEFREE |
These studies also support the concept that MC4R activation is critical for obesity-induced hypertension as well as other forms of hypertension associated with increased SNS activity.
|
31028563 |
2019 |
|
Hypertensive disease
|
0.200 |
Biomarker
|
group |
BEFREE |
However, when MC4R-deficient rats were food restricted to prevent obesity, CIH-induced hypertension was attenuated by 32%.
|
30466186 |
2019 |
|
Hypertensive disease
|
0.200 |
Biomarker
|
group |
BEFREE |
Although blockade of MC4R may lead to increased body weight during pregnancy, we tested the hypothesis that placental ischemia-induced hypertension is attenuated in obese MC4R-deficient pregnant rats.
|
30571561 |
2019 |
|
Hypertensive disease
|
0.200 |
Biomarker
|
group |
BEFREE |
Haploinsufficiency of the melanocortin-4 receptor, the most common monogenetic obesity syndrome in humans, is associated with a reduction in autonomic tone, bradycardia, and incidence of obesity-associated hypertension.
|
28829041 |
2017 |
|
Hypertensive disease
|
0.200 |
AlteredExpression
|
group |
BEFREE |
In this review we discuss the importance of the brain POMC-MC4R system in regulating SNS activity and BP in obesity and other forms of hypertension.
|
28274841 |
2017 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Furthermore, multifactor dimensionality reduction analysis revealed that the combination of MC4R variant (rs17782313), hypertension and smoking habit was significantly associated with increased risk of LAA stroke (p < 0.0001, OR (95% CI) = 6.57 (4.79-9.01)).
|
27701175 |
2016 |
|
Hypertensive disease
|
0.200 |
Biomarker
|
group |
BEFREE |
Thus, Mc4r in the PVH appears to be required for early-life programming of hypertension arising from either maternal obesity or neonatal hyperleptinemia.
|
27791019 |
2016 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
No association between the FTO or MC4R genes with daytime hypertension was found in this Chinese population (p > 0.05).
|
26324055 |
2016 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
In addition, three SNPs were significantly associated with hypertension risk after adjustment for age and sex (FTO rs9939609: odds ratio (OR)=1.35, 95% confidence interval (CI) 1.12-1.62, P=0.001; MC4R rs17782313: OR=1.22, 95% CI 1.06-1.42, P=0.007; GNPDA2 rs10938397: OR=1.17, 95% CI 1.02-1.34, P=0.021).
|
23588626 |
2013 |
|
Hypertensive disease
|
0.200 |
AlteredExpression
|
group |
BEFREE |
These findings provide a cellular correlate of the autonomic side effects associated with MC4R agonists and demonstrate a role for MC4Rs expressed in cholinergic neurons in the regulation of insulin levels and in the development of obesity-induced hypertension.
|
23374353 |
2013 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Common genetic variants of FTO rs9939609 have positive associations with BMI and neck circumference and MC4R rs17782313 in women, but a negative association with diastolic and mean blood pressure in men with hypertension.
|
23849767 |
2013 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Humans with loss-of-function mutations in the melanocortin 4 receptor (MC4R) are an ideal group of subjects in whom the importance of melanocortin signalling in linking obesity to hypertension can be studied.
|
21062377 |
2011 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Individuals with dysfunctional mutations in the melanocortin-4 receptor gene (MC4R) are subject to obesity without developing hypertension.
|
20147580 |
2010 |
|
Hypertensive disease
|
0.200 |
Biomarker
|
group |
BEFREE |
The prevalence of hypertension was markedly lower in the MC4R-deficient subjects than in the control subjects (24% vs. 53%, P=0.009).
|
19092146 |
2009 |
|
Hypertensive disease
|
0.200 |
Biomarker
|
group |
LHGDN |
The prevalence of hypertension was markedly lower in the MC4R-deficient subjects than in the control subjects (24% vs. 53%, P=0.009).
|
19092146 |
2009 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Does greater adiposity increase blood pressure and hypertension risk?: Mendelian randomization using the FTO/MC4R genotype.
|
19470880 |
2009 |
|
Hypertensive disease
|
0.200 |
Biomarker
|
group |
HPO |
|
|
|