MC4R, melanocortin 4 receptor, 4160

N. diseases: 149; N. variants: 58
Disease: LEPTIN RECEPTOR DEFICIENCY ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3554225
Disease: LEPTIN RECEPTOR DEFICIENCY
LEPTIN RECEPTOR DEFICIENCY 		0.020 Biomarker disease BEFREE Specifically, setmelanotide was found to be effective by inducing biased signalling of the MC4R and thereby reducing feelings of hunger and leading to substantial weight loss in patients with POMC or leptin receptor deficiency. 30642682 2019
CUI: C3554225
Disease: LEPTIN RECEPTOR DEFICIENCY
LEPTIN RECEPTOR DEFICIENCY 		0.020 Biomarker disease BEFREE MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency. 29736023 2018