|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
<i>In vivo</i>, anti-CD30-MCC-DM1 was found to be capable of inducing tumor regression in subcutaneous inoculation of Karpas 299 (anaplastic large cell lymphoma), HH (cutaneous T-cell lymphoma) and L428 (Hodgkin's disease) cell models.
|
31161871 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The adenomatous polyposis coli (APC) tumor suppressor has dual functions in Wnt/β-catenin signaling and accurate chromosome segregation and is frequently mutated in colorectal cancers.
|
29348204 |
2018 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
However, miRNAs that directly target the mutated in colorectal cancer (MCC) gene, a tumor suppressor which is downregulated or inactivated in colorectal cancer, remain largely unknown.
|
28638476 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To elucidate potential roles of Wnt/β-catenin signal-associated gene methylation in GNCCP, we performed β-catenin immunostaining and methylation-specific polymerase chain reaction (PCR) for their associated genes, including SFRPs, APC, AXIN2, and MCC, in 26 GNCCPs [i.e., 11 intramucosal (GNCCP-Ms) and 15 submucosal tumors (GNCCP-SMs)], and compared with 27 fundic gland polyps (FGPs), 12 FGPs with dysplasia (FGP-Ds), 27 conventional gastric adenocarcinomas (CGAs).
|
28105693 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The TNBC patients in stage III/IV having reduced expression of MCC in the tumors showed poor prognosis.
|
27208794 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The Adenomatous Polyposis Coli (APC) tumor suppressor is most commonly mutated in colorectal cancers such as familial adenomatous polyposis (FAP); as well as many other epithelial cancers like breast, pancreatic, and lung cancer.
|
24200292 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In the first example, 4/19 (21.1%) donors presented germline retrotransposition events in the tumor suppressor mutated in colorectal cancers (MCC).
|
23540693 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Importantly, our analyses revealed that, while known CRC driver genes APC and SMAD4 were disrupted in both human colorectal tumors and tumors from ApcMin/+ mice, the questionable MCC gene was disrupted in human tumors but appeared to be intact in mouse tumors.
|
20707908 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Overall, these results indicate that MCC-555 has a potent tumor suppressor activity in intestinal tumorigenesis, likely involving MUC2 up-regulation by ERK and PPARgamma pathways.
|
18790758 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The morphological and molecular features of MCC1 and its corresponding primary tumor are consistent with a model for non-invasive MCC, where K-RAS, P16, P53 and MUC1 alterations are pre-invasive changes associated with progression of malignancy of MCT from adenoma to carcinoma.
|
15688169 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
LOH at MCC gene was not detected either in tumor or in leukoplakia DNAs.
|
12901725 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Nude mice developed solid tumors with similar histology to the original tumor after subcutaneous and intravenous injections of cultured MCC-1, and malignant ascites was seen after intraperitoneal injection.
|
11319762 |
2001 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Allelic loss involving the tumor suppressor genes APC and MCC and expression of the APC protein in the development of dysplasia and carcinoma in Barrett esophagus.
|
11338478 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, the observed LOH levels at APC/MCC (5q21), RB (13q14), and WT-1 (11p13) could represent a functional loss of the corresponding tumor suppressor gene in some GCTs or reflect the loss of sequences in the same general chromosome region but involving a different tumor suppressor locus.
|
7796415 |
1995 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Frequent genetic abnormalities include mutation of the familial adenomatous polyposis (APC) and/or the mutated in colorectal cancer (MCC) genes on chromosome 5q21, activation of K-ras and loss of the tumour suppressor genes p53 and DCC (deleted in colorectal cancer).
|
8318691 |
1993 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Loss of heterozygosity (LOH) at APC and MCC gene loci (both mapped to 5q21) was investigated in 24 surgical specimens of primary gastric carcinomas using the polymerase chain reaction after tumor cell enrichment by cell sorting based on differences in DNA content.
|
8226275 |
1993 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The results confirm that the putative tumor suppressor gene for HCC without cirrhosis on chromosome 5q is distinct from the MCC and APC genes.
|
8402727 |
1993 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The candidate tumor suppressor genes from these regions are, respectively, MCC and/or APC, p53, and DCC.
|
1347643 |
1992 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These data suggest that (a) allelic deletions including these tumor suppressor genes are important in the formation and/or progression of most esophageal cancers; (b) allelic deletions involving MCC may not occur independently of deletions involving other tumor suppressor genes; and (c) the accumulation of multiple allelic deletions involving specific tumor suppressor genes may be important in most esophageal tumorigenesis or tumor evolution.
|
1423299 |
1992 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Two of these genes (MCC and APC) were found to be somatically altered by point mutation, deletion or insertion in tumors of sporadic colorectal cancer patients.
|
1339098 |
1992 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The MCC gene is a candidate as a tumor suppressor gene for colorectal neoplasms.
|
1347524 |
1992 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Another candidate tumor-suppressor gene also was identified on chromosome 5, mcc (for mutated in colorectal cancers).
|
1516027 |
1992 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Two genes on 5q21 that are tightly linked to FAP (MCC and APC) were found to be somatically altered in tumors from sporadic colorectal cancer patients.
|
1651563 |
1991 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The rearrangement in the tumor disrupted the coding region of the MCC gene.
|
1848370 |
1991 |