Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024530
Disease: Malaria
Malaria
0.020 Biomarker disease BEFREE Parent DBL-CIDR head structures were better indicators of malaria exposure. 31409360 2019
CUI: C0006012
Disease: Borderline Personality Disorder
Borderline Personality Disorder
0.020 Biomarker disease BEFREE In the present study, we aimed to investigate the role of DNA methylation of APBA3 and MCF2 as possible biomarkers for treatment outcome in BPD, whilst validating the previous findings of differential DNA methylation in a cohort of 44 BPD patients and 44 well-matched healthy control individuals. 29274998 2018
CUI: C0006012
Disease: Borderline Personality Disorder
Borderline Personality Disorder
0.020 GeneticVariation disease BEFREE Bead chip technology and quantitative bisulfite pyrosequencing showed a significantly increased methylation at CpG sites of APBA2 (1.1 fold) and APBA3 (1.1 fold), KCNQ1 (1.5 fold), MCF2 (1.1 fold) and NINJ2 (1.2 fold) in BPD patients. 24367640 2013
CUI: C0024530
Disease: Malaria
Malaria
0.020 Biomarker disease BEFREE These structural insights have clear implications in using CSA-binding DBL domains for vaccines against placental malaria as it is proposed that the various CSA-binding DBL domains on var2CSA will recognize their CSA ligands differently. 19374733 2009
CUI: C1845668
Disease: Perisylvian syndrome
Perisylvian syndrome
0.010 GeneticVariation disease BEFREE Strikingly, we find that the CBPS-associated MCF2 mutation impairs cortical laminar positioning, supporting the hypothesis that alterations in the process of embryonic neuronal migration can lead to rare cases of CBPS. 31846234 2020
CUI: C0010709
Disease: Cyst
Cyst
0.010 Biomarker disease BEFREE Differences in DBL-cysts formation in vitro in response to exogenous stress were observed between recombinant genotype isolates and the typical genotypes. 31628896 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.010 Biomarker group BEFREE DBL has promising clinical potential both in cancer and HIV research. 28472687 2017
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.010 Biomarker group BEFREE DBL has promising clinical potential both in cancer and HIV research. 28472687 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.010 AlteredExpression disease BEFREE Notably, upregulated MCF2 and MITF expression was also observed in 21% and 33% of 24 human hepatocellular carcinomas analyzed. 29383183 2017
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.010 Biomarker phenotype BEFREE The invasion process requires recognition of RBC surface receptors by proteins of the Plasmodium Duffy binding like erythrocyte binding like (DBL-EBP) family. 19879379 2010
CUI: C0205851
Disease: Germ cell tumor
Germ cell tumor
0.010 Biomarker disease BEFREE Mutational analysis of proto-oncogene Dbl on Xq27 in testicular germ cell tumors reveals a rare SNP in a patient with bilateral undescended testis. 19373475 2009
CUI: C0431663
Disease: Bilateral Cryptorchidism
Bilateral Cryptorchidism
0.010 GeneticVariation disease BEFREE Mutational analysis of proto-oncogene Dbl on Xq27 in testicular germ cell tumors reveals a rare SNP in a patient with bilateral undescended testis. 19373475 2009
CUI: C0342344
Disease: Hypoparathyroidism - X-linked
Hypoparathyroidism - X-linked
0.010 Biomarker disease BEFREE X-linked hypoparathyroidism (HPT) has been mapped to a 988-kb region on chromosome Xq27 that contains three genes, MCF2/DBL, SOX3, and U7snRNA homologue, and a partial cDNA, AS6. 15533723 2004
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.010 AlteredExpression group BEFREE We found that while the dbl gene is consistently found expressed in Ewing's sarcoma as a single mRNA species, of approximately 5.0 kb, it is generally absent in two seemingly related categories of tumors, neuroblastoma and neuroepithelioma. 2666909 1989
CUI: C0206663
Disease: Neuroectodermal Tumor, Primitive
Neuroectodermal Tumor, Primitive
0.010 GeneticVariation disease BEFREE We found that while the dbl gene is consistently found expressed in Ewing's sarcoma as a single mRNA species, of approximately 5.0 kb, it is generally absent in two seemingly related categories of tumors, neuroblastoma and neuroepithelioma. 2666909 1989
CUI: C0553580
Disease: Ewings sarcoma
Ewings sarcoma
0.010 AlteredExpression disease BEFREE We found that while the dbl gene is consistently found expressed in Ewing's sarcoma as a single mRNA species, of approximately 5.0 kb, it is generally absent in two seemingly related categories of tumors, neuroblastoma and neuroepithelioma. 2666909 1989
CUI: C4048305
Disease: Neuroepithelioma
Neuroepithelioma
0.010 GeneticVariation disease BEFREE We found that while the dbl gene is consistently found expressed in Ewing's sarcoma as a single mRNA species, of approximately 5.0 kb, it is generally absent in two seemingly related categories of tumors, neuroblastoma and neuroepithelioma. 2666909 1989
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.010 Biomarker group BEFREE The DBL transforming gene was originally identified by transfection of NIH 3T3 cells with DNA from a human B-cell lymphoma. 3281159 1988