ART1, ADP-ribosyltransferase 1, 417

N. diseases: 27; N. variants: 0
Disease: Glomerulonephritis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis 		0.010 AlteredExpression disease BEFREE CD38-deficient (Cd38<sup>-/-</sup>) but not ART2-deficient (Art2<sup>-/-</sup>) mice developed less severe lupus compared to wild type (WT) mice, and their protective phenotype consisted of (i) decreased IFN-I-stimulated gene expression, (ii) decreased numbers of peritoneal CCR2<sup>hi</sup>Ly6C<sup>hi</sup> inflammatory monocytes, TNF-α-producing Ly6G<sup>+</sup> neutrophils and Ly6C<sup>lo</sup> monocytes/macrophages, (iii) decreased production of anti-single-stranded DNA and anti-nRNP autoantibodies, and (iv) ameliorated glomerulonephritis. 29463868 2018