|
Colon Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
In the present study, mouse colon carcinoma CT26 cells were infected with a lentivirus to produce ART1 gene silencing or overexpression, and were then subcutaneously transplanted.
|
28138708 |
2017 |
|
Colon Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Our data suggest that ART1 could regulate EMT by regulating the RhoA/ROCK1/AKT/β-catenin pathway and its downstream factors (snail1, vimentin, N-cadherin and E-cadherin) and that it therefore plays an important role in the progression of colon carcinoma.
|
27277835 |
2016 |
|
Colon Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Previous studies have demonstrated that ART1 promotes proliferation, invasion and metastasis in colon carcinoma.
|
26847718 |
2016 |
|
Colon Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
In this study, using immunohistochemical analysis, we detected a higher expression of PARP-1 and ART1 in 63 samples from patients with colon carcinoma compared to 10 samples of normal colonic mucosa; our results revealed a positive correlation between the expression of PARP-1 and ART1 in the 63 human colon carcinoma tissue samples.
|
23652727 |
2013 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
To observe the effects of ART1 and BCP on tumor growth in vivo, CT26 cell tumors were successfully transplanted into BALB/c mice with T2DM.
|
30066849 |
2018 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
The results demonstrated that ART1 gene silencing inhibited the growth of the spleen transplanted tumor and its ability to spread to the liver via metastasis.
|
28138708 |
2017 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
The results demonstrated that ART1 gene silencing inhibited the growth of the spleen transplanted tumor and its ability to spread to the liver via metastasis.
|
28138708 |
2017 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
The effect of ART1 on EMT and carcinoma metastasis was also verified in a liver metastasis model of BALB/c mice.
|
27277835 |
2016 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Previous studies have demonstrated that ART1 promotes proliferation, invasion and metastasis in colon carcinoma.
|
26847718 |
2016 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
In a mouse xenograft model, we noted that the tumor microvessel density (MVD) was significantly increased in intrasplenic transplanted ART1‑cDNA CT26 tumors but decreased in intrasplenic transplanted ART1‑shRNA tumors.
|
26847718 |
2016 |
|
Tuberculosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Participants classified by a study algorithm as having high probability of tuberculosis (positive urine lipoarabinomannan assay, body-mass index <18·5 kg/m<sup>2</sup>, or haemoglobin concentration <100 g/L) were recommended to start tuberculosis treatment immediately followed by ART 2 weeks later; participants classified as medium probability (tuberculosis symptoms, no high probability criteria) were recommended to have symptom-guided investigation; and participants classified as low probability (no tuberculosis symptoms or high probability criteria) were recommended to start ART immediately.
|
31727580 |
2020 |
|
Human immunodeficiency virus (HIV) II infection category B1
|
0.020 |
Biomarker
|
disease |
BEFREE |
Compared with HIV-negative women, abnormal pathology was more likely among HIV-positive women, both those on ART <2 years (adjusted prevalence ratio, 2.5; 95% confidence interval, 1.2-5.0) and those on ART 2 years or longer (adjusted prevalence ratio, 2.1; 95% confidence interval, 1.0-4.2).
|
30308532 |
2019 |
|
Tuberculosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Multiple micronutrientsWe conducted analyses across antiretroviral therapy (ART)-naive adults (3 trials, 1448 participants), adults on antiretroviral therapy (ART) (1 trial, 400 participants), and ART-naive adults with concurrent active tuberculosis (3 trials, 1429 participants).
|
28518221 |
2017 |
|
Secondary malignant neoplasm of liver
|
0.020 |
Biomarker
|
disease |
BEFREE |
To observe the effect of ART1 on tumor growth or liver metastasis in vivo, a spleen transplant tumor model of CT26 cells in BALB/c mice was successfully constructed.
|
28138708 |
2017 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
However, the effect of ART1 on the proliferation and invasion of colon carcinoma in vivo has yet to be elucidated.
|
28138708 |
2017 |
|
Human immunodeficiency virus (HIV) II infection category B1
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Many 2013 cohort participants were new/recent HIV diagnoses (34%) and known HIV<sup>+</sup> with <1 month ART (20%), but a significant proportion were receiving ART 1-4 months (11%) and >4 months (30%).
|
28584857 |
2017 |
|
Secondary malignant neoplasm of liver
|
0.020 |
Biomarker
|
disease |
BEFREE |
The effect of ART1 on EMT and carcinoma metastasis was also verified in a liver metastasis model of BALB/c mice.
|
27277835 |
2016 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Thus, we suggest that ART1 plays an important role in the invasion of CRC cells and the metastasis of CRC.
|
26847718 |
2016 |
|
Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Results:</b> The ART-2-coated liposomes encapsulating an antiarthritic drug, dexamethasone (DEX), were more effective in inhibiting arthritis progression than control-DEX liposomes or free DEX, despite a comparable safety profile.
|
30938236 |
2019 |
|
Astigmatism
|
0.010 |
Biomarker
|
disease |
BEFREE |
Comparison of visual quality in cataract patients with low astigmatism after ART2 or ReSTOR intraocular lens implantation.
|
30918811 |
2019 |
|
Regular astigmatism - corneal
|
0.010 |
Biomarker
|
disease |
BEFREE |
ART2 is more suitable than ReSTOR for cataract patients with regular corneal astigmatism 0.75-1.0 D with-the-rule or 0.5-0.75 D against-the-rule.
|
30918811 |
2019 |
|
Malignant Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Hyperglycemia, which is a risk factor of cancer, is a common feature of T2DM; however, the effects of ART1 on glycolysis and energy metabolism in CRC cells under high-glucose conditions remains to be elucidated.
|
30066849 |
2018 |
|
Glomerulonephritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CD38-deficient (Cd38<sup>-/-</sup>) but not ART2-deficient (Art2<sup>-/-</sup>) mice developed less severe lupus compared to wild type (WT) mice, and their protective phenotype consisted of (i) decreased IFN-I-stimulated gene expression, (ii) decreased numbers of peritoneal CCR2<sup>hi</sup>Ly6C<sup>hi</sup> inflammatory monocytes, TNF-α-producing Ly6G<sup>+</sup> neutrophils and Ly6C<sup>lo</sup> monocytes/macrophages, (iii) decreased production of anti-single-stranded DNA and anti-nRNP autoantibodies, and (iv) ameliorated glomerulonephritis.
|
29463868 |
2018 |
|
Hypertensive disease
|
0.010 |
Biomarker
|
group |
BEFREE |
This study aimed to evaluate the effect of ART1 antibodies on allograft function and hypertension in stable kidney transplant recipients.
|
29507275 |
2018 |
|
Primary malignant neoplasm
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Hyperglycemia, which is a risk factor of cancer, is a common feature of T2DM; however, the effects of ART1 on glycolysis and energy metabolism in CRC cells under high-glucose conditions remains to be elucidated.
|
30066849 |
2018 |