|
Papillary thyroid carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MCM3 protein expression in follicular and classical variants of papillary thyroid carcinoma.
|
23821456 |
2014 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
MCM3 expression was found to be up-regulated in glioma and correlated with overall survival in patients with WHO grade III tumor.
|
25046975 |
2014 |
|
Squamous cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
MCM3: A Novel Proliferation Marker in Oral Squamous Cell Carcinoma.
|
27258565 |
2018 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
MCM3 expression was detected in 38 (90%) tumors, and PCNA expression in 28 (67%), yet none of clinicopathological factors was related to them.
|
28493257 |
2018 |
|
Cutaneous Melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Four studies attempted to define the prognostic signature of skin melanoma but only one based the study on the primary tumor resulting in heterogenous signatures with a minimal overlap (MCM3 and NFKBIZ).
|
20177751 |
2010 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Four studies attempted to define the prognostic signature of skin melanoma but only one based the study on the primary tumor resulting in heterogenous signatures with a minimal overlap (MCM3 and NFKBIZ).
|
20177751 |
2010 |
|
Secondary malignant neoplasm of bone
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, immunohistochemical analysis of MCM3 protein levels in human prostate tissue specimens showed elevated expression in bone metastasis and advanced human prostate cancer tissue samples.
|
28424404 |
2017 |
|
Malignant neoplasm of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, immunohistochemical analysis of MCM3 protein levels in human prostate tissue specimens showed elevated expression in bone metastasis and advanced human prostate cancer tissue samples.
|
28424404 |
2017 |
|
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, immunohistochemical analysis of MCM3 protein levels in human prostate tissue specimens showed elevated expression in bone metastasis and advanced human prostate cancer tissue samples.
|
28424404 |
2017 |
|
Autosomal Recessive Polycystic Kidney Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Genomic structure of the gene for the human P1 protein (MCM3) and its exclusion as a candidate for autosomal recessive polycystic kidney disease.
|
10780780 |
2000 |
|
Glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High expression of MCM 2, MCM3 and MCM7 mRNA correlated with poor outcome and may be clinically useful molecular prognostic markers in glioma.
|
25046975 |
2014 |
|
Renal Cell Carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
In this study, we demonstrated that polo-like kinase 1 (PLK1)-mediated MCM3 phosphorylation regulates proliferation and apoptosis in RCC.
|
31186514 |
2019 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
In this study, we demonstrated that polo-like kinase 1 (PLK1)-mediated MCM3 phosphorylation regulates proliferation and apoptosis in RCC.
|
31186514 |
2019 |
|
Diabetic Nephropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we further examined the roles of SND p102 in diabetic nephropathy (DN)-induced glomerulosclerosis.
|
30150789 |
2018 |
|
Glomerulosclerosis (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we further examined the roles of SND p102 in diabetic nephropathy (DN)-induced glomerulosclerosis.
|
30150789 |
2018 |
|
Medulloblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we showed the frequent deregulation of MCM2 and MCM3 expression in 7 MB cell lines and 31 clinical samples.
|
20661220 |
2010 |
|
Childhood Medulloblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we showed the frequent deregulation of MCM2 and MCM3 expression in 7 MB cell lines and 31 clinical samples.
|
20661220 |
2010 |
|
Adult Medulloblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we showed the frequent deregulation of MCM2 and MCM3 expression in 7 MB cell lines and 31 clinical samples.
|
20661220 |
2010 |
|
Brain Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Minichromosome maintenance protein 3 elicits a cancer-restricted immune response in patients with brain malignancies and is a strong independent predictor of survival in patients with anaplastic astrocytoma.
|
15671553 |
2005 |
|
B-Cell Lymphomas
|
0.010 |
AlteredExpression
|
group |
BEFREE |
MYB can up-regulate MCM3 (minichromosome maintenance 3) and MCM7 expression; PGR can suppress BCL2 (B-cell lymphoma 2) expression; MYC can inhibit TGFB2 (transforming growth factor, beta 2) expression.
|
23098454 |
2012 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Nude mice who received injections of HEK 293 cells stably transfected with MCM3 formed tumors in 6 weeks.
|
15623617 |
2004 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Our findings indicate that although both MCM3 and Ki-67 represent reliable markers of cellular proliferation in OSCC, as MCM3 expression does not appear to be influenced by external factors, this protein may emerge as a novel marker of cellular proliferation in these types of tumors.
|
27258565 |
2018 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Our study indicates that determination of MCM3 expression level will facilitate the assessment of many different human malignancies in tumor diagnosis, and MCM3 is involved in multiple types of human carcino-genesis.
|
15623617 |
2004 |
|
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Overexpression of BUB1B, CCNB1, CDC7, CDC20, and MCM3 in HCC tissues accounted for poorer overall survival (OS) and disease-free survival (DFS) in HCC patients (all log rank <i>P</i> < 0.05).
|
30363964 |
2018 |
|
Adrenal Cortical Adenoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Specimens of 81 adrenocortical adenomas and 3 adrenocortical carcinomas were stained with antibodies against MCM-3, 5, 7 and Ki-67.
|
30842144 |
2019 |