|
Synovitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
MCP joints with more severe synovitis ('bad joints') demonstrated significantly lower dGEMRIC values compared to MCP joints with less severe synovitis ('good joints') at time-points 0 and 3 months (p=0.002; p=0.019, respectively).
|
29998824 |
2019 |
|
Thalassemia
|
0.010 |
GeneticVariation
|
group |
BEFREE |
HDAd5/35++ vectors for in vivo gene therapy of thalassemia had a unique capsid that targeted primitive HSPCs through human CD46, a relatively safe SB100X transposase-based integration machinery, a micro-LCR-driven γ-globin gene, and an MGMT(P140K) system that allowed for increasing the therapeutic effect by short-term treatment with low-dose O6-benzylguanine plus bis-chloroethylnitrosourea.
|
30422819 |
2019 |
|
Polyendocrinopathies, Autoimmune
|
0.010 |
Biomarker
|
group |
BEFREE |
We found that placental DAF and CD46 decreased in β2GPI passively immunized APS model mice, accompanied by C3 deposition, neutrophil infiltration and increased proinflammatory cytokine levels detected in its placenta.
|
31091357 |
2019 |
|
Essential Tremor
|
0.010 |
Biomarker
|
disease |
BEFREE |
Significant atrophy of bilateral MCP and ICP and bilateral cerebellar GM was observed in ET.
|
31161314 |
2019 |
|
Thalassemia Intermedia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We showed in "healthy" human CD46-transgenic mice and in a mouse model of thalassemia intermedia that our in vivo approach resulted in stable γ-globin expression in the majority of circulating red blood cells.
|
30422819 |
2019 |
|
Congenital infectious disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Further, we demonstrate a CD46-dependent entry pathway of virus infection in trophoblasts, but not in fibroblasts, highlighting the complexity of CMV entry and identifying CD46 as an entry factor in congenital infection.
|
31221976 |
2019 |
|
Cerebellar signs
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
This study aims to evaluate the macrostructural integrity of the superior, middle, and inferior cerebellar peduncles (SCP, MCP, ICP) and cerebellar gray and white matter (GM, WM) volumes in patients with ET, and compare these volumes between patients with and without cerebellar signs (ETc and ETnc).
|
31161314 |
2019 |
|
Adult Acute Lymphocytic Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A total of 96 children with ALL undergoing therapy with MCP-841 protocol were screened for all the ten exons of TPMT, exon 2, exon 3 and intron 2 of ITPA using bidirectional sequencing.
|
30806759 |
2019 |
|
Measles
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
CD46 expression and MV infection were inhibited by nutlin3a in primary p53-competent myeloma cells, but not in p53-deficient myeloma cells, and the latter were highly sensitive to MV infection.
|
30530776 |
2018 |
|
Prostatic Cancer, Castration-Resistant
|
0.300 |
Biomarker
|
disease |
CTD_human |
Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer.
|
30185663 |
2018 |
|
Prostatic Neoplasms, Castration-Resistant
|
0.300 |
Biomarker
|
disease |
CTD_human |
Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer.
|
30185663 |
2018 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Overall, our findings suggest that bladder cancer cells overexpress both CAR and CD46, and that adenoviral cancer gene therapy targeting CD46 represents a more suitable therapy option than a CAR-targeting therapy, especially in patients with low risk bladder cancers.
|
30201920 |
2018 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Therefore, inhibitors of TLX transcriptional activity may have a significant impact on the treatment of several critical malignancies.
|
30441799 |
2018 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Pairwise analysis identified five orphan NRs (including RORβ, TLX, COUP-TFII, NURR1 and LRH-1) that showed common upregulation in both mRNA and protein levels in the prostatospheroids and castration-relapse VCaP-CRPC xenografts, and overexpression of these orphan NRs could increase cancer stem cell marker expressions and enhance spheroid formation capacity in prostate cancer cells, suggesting that these orphan NRs might perform positive roles in the growth regulation of PCSCs and castration-resistant prostate cancer.
|
29042395 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
CD46 is overexpressed in primary tumor tissue and CRPC (localized and metastatic; adeno and NEPC), but expressed at low levels on normal tissues except for placental trophoblasts and prostate epithelium.
|
30185663 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To improve the therapy efficiency as a PTT agent, the MCP NPs are further modified with functional polyethylene glycol (PEG) and thiol terminal cyclic arginine-glycine-aspartic acid peptide, respectively: the first one is to increase the stability, biocompatibility, and blood circulation time of MCP NPs in vivo; the second one is to increase the tumor accumulation of MCP-PEG NPs and improve their therapeutic efficiency as photothermal agent.
|
29938191 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In a human EJ bladder cancer xenograft mouse model, with either overexpressed or suppressed CD46 expression levels, Ad5/35-tk followed by ganciclovir (GCV) treatment significantly affected tumor growth, whereas Ad5-tk/GCV had only minimal effects.
|
30201920 |
2018 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
p53 regulates CD46 expression and measles virus infection in myeloma cells.
|
30530776 |
2018 |
|
RESTING HEART RATE
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system.
|
29769521 |
2018 |
|
Primary malignant neoplasm
|
0.090 |
Biomarker
|
group |
BEFREE |
Overall, our findings suggest that bladder cancer cells overexpress both CAR and CD46, and that adenoviral cancer gene therapy targeting CD46 represents a more suitable therapy option than a CAR-targeting therapy, especially in patients with low risk bladder cancers.
|
30201920 |
2018 |
|
Primary malignant neoplasm
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Pairwise analysis identified five orphan NRs (including RORβ, TLX, COUP-TFII, NURR1 and LRH-1) that showed common upregulation in both mRNA and protein levels in the prostatospheroids and castration-relapse VCaP-CRPC xenografts, and overexpression of these orphan NRs could increase cancer stem cell marker expressions and enhance spheroid formation capacity in prostate cancer cells, suggesting that these orphan NRs might perform positive roles in the growth regulation of PCSCs and castration-resistant prostate cancer.
|
29042395 |
2018 |
|
Brain Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Orphan nuclear receptor TLX (NR2E1) plays a critical role in the regulation of neural stem cells (NSC) as well as in the development of NSC-derived brain tumors.
|
30441799 |
2018 |
|
Malignant neoplasm of prostate
|
0.050 |
Biomarker
|
disease |
BEFREE |
Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer.
|
30185663 |
2018 |
|
Malignant neoplasm of prostate
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Our previous study shows that the orphan nuclear receptor TLX (NR2E1), which is upregulated in prostate cancer, plays an oncogenic role in prostate carcinogenesis by suppressing oncogene-induced senescence.
|
29555975 |
2018 |
|
Carcinogenesis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Our previous study shows that the orphan nuclear receptor TLX (NR2E1), which is upregulated in prostate cancer, plays an oncogenic role in prostate carcinogenesis by suppressing oncogene-induced senescence.
|
29555975 |
2018 |