|
Malignant tumor of cervix
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results have revealed a novel mechanism by which high-risk HPVs promote motility and angiogenesis of CC by inhibiting expression of lnc-CCDST to disrupt MDM2 and DHX9 interaction, and DHX9 degradation, and identified a potential therapeutic target for CC.
|
30518908 |
2019 |
|
Malignant tumor of cervix
|
0.100 |
Biomarker
|
disease |
BEFREE |
Correction to: A DHX9-lncRNA-MDM2 interaction regulates cell invasion and angiogenesis of cervical cancer.
|
30804472 |
2019 |
|
Malignant tumor of cervix
|
0.100 |
Biomarker
|
disease |
BEFREE |
The involvement of E6, p53, p16, MDM2 and Gal-3 in the clinical outcome of patients with cervical cancer.
|
29085443 |
2017 |
|
Malignant tumor of cervix
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Several factors may contribute to cervical cancer (CC) development, including genetic variants such as TP53 and MDM2 gene polymorphisms.
|
25181402 |
2015 |
|
Malignant tumor of cervix
|
0.100 |
Biomarker
|
disease |
BEFREE |
To achieve this, AG and TV crude extracts were utilized to screen for apoptosis induction, inhibition of cell proliferation followed by elucidation of the role of Bax, Bcl-2, p53, Rb, RBBP and Mdm2 genes in cervical cancer.
|
24993114 |
2014 |
|
Malignant tumor of cervix
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the results of the present study suggest that homozygous GG alleles of MDM2 T309G polymorphism might be a risk factor for cervical cancer among Asians.
|
24532430 |
2014 |
|
Malignant tumor of cervix
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings not only indicate NAC as a rational approach for better treatment of cervical cancer with improved therapeutic outcomes, due partly to the ability of cisplatin to promote the p53:miR-34a:E2F1 positive feed-forward loop and the p53:miR-605:Mdm2 positive feedback loop.
|
24335178 |
2013 |
|
Malignant tumor of cervix
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, Arginine at codon72 of p53 and GG genotype at 309 in P2 of MDM2 together reveal a direct proportionality with the tumor grade of cervical cancer along with HPV infection in postmenopausal women.
|
23210739 |
2013 |
|
Malignant tumor of cervix
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found no association between MDM2 SNP309 or NQO1 SNP465 and cervical cancer.
|
20200430 |
2010 |
|
Malignant tumor of cervix
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that SNP309 MDM2 may not be a risk factor for cervical cancer.
|
18023538 |
2007 |
|
Malignant tumor of cervix
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Deregulation of the apoptotic machinery plays a major role in cell death, cellular transformation and cancer. p53, Bcl-2, Bcl-XL, Bax and Mdm2 mRNA expression patterns were evaluated in tissue samples with cervical intraepithelial neoplasia (CIN) and cervical cancer compared to those of normal cervical tissues, and correlated with the underlying cervical lesions.
|
15832769 |
2005 |