|
Endometrial Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The EC cells were then treated with CP‑31398 (2 µg/ml), and were transfected with siRNA against MDM2 or an MDM2 overexpression plasmid in order to examine the effects of CP‑31398 and MDM2 on EC cell activities.
|
30628640 |
2019 |
|
Endometrial Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MDM2 SNP309 plays a role in EC onset in postmenopausal women.
|
31028217 |
2019 |
|
Endometrial Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We performed the present meta-analysis to give a comprehensive conclusion of the association between MDM2 SNP309 polymorphism and endometrial cancer susceptibility.
|
30544386 |
2018 |
|
Endometrial Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found the MDM2 del1518 del variant to be associated with reduced risk of endometrial cancer among individuals carrying the MDM2 SNP309TT genotype.
|
28158999 |
2017 |
|
Endometrial Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the study found that MDM2 rs2279744 polymorphism was significantly associated with endometrial cancer risk in a Chinese Han population.
|
29096752 |
2017 |
|
Endometrial Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CONCLUSIONS Our meta-analysis provides evidence that MDM2 T309G polymorphism is associated with endometrial cancer, especially in Caucasians.
|
27604213 |
2016 |
|
Endometrial Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our findings suggest that both the SNP55 status and the NFκB p50 activity are important in the transcriptional regulation of MDM2 in endometrial cancers.
|
26293665 |
2015 |
|
Endometrial Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Overall, the meta-analysis demonstrated that the MDM2 SNP309 polymorphism may be associated with increased risk of endometrial cancer.
|
24792886 |
2014 |
|
Endometrial Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Co-occurrence of some MDM2 SNP309 and TP53 codon 72 polymorphisms seems to influence EC risk, involving grading and staging of this neoplasm at the same time.
|
25316267 |
2014 |
|
Endometrial Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
While SNP309G enhances Sp1 transcription factor binding and MDM2 transcription, SNP285C antagonizes Sp1 binding and reduces the risk of breast-, ovary- and endometrial cancer.
|
25327560 |
2014 |
|
Endometrial Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our pooled data suggest evidence for a major role of MDM2 rs2279744 polymorphism in the carcinogenesis of endometrial cancer, especially among Caucasian populations.
|
24293392 |
2014 |
|
Endometrial Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The association between the MDM2 SNP309 polymorphism and endometrial cancer risk was assessed by odds ratios (ORs) together with their 95% confidence intervals (CIs).
|
24423195 |
2013 |
|
Endometrial Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we investigated the effects of germline single nucleotide polymorphisms in murine double minute 2 (MDM2) SNP309, TP53 Arg72Pro, ESR1 PvuII and XbaI, and p21 codon 31 on endometrial cancer risk.
|
23624782 |
2013 |
|
Endometrial Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Overall, the meta-analysis suggested that the GG genotype of MDM2 SNP309 was significantly associated with the increased endometrial cancer risk.
|
21547352 |
2011 |
|
Endometrial Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Alterations of p53 pathway (p14(ARF)/MDM2/p53) play a crucial role in the development and progression of various human neoplasms, including endometrial carcinoma (EC).
|
20683407 |
2010 |
|
Endometrial Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that homozygous GG genotype of MDM2-SNP309 may be a risk factor for postmenopausal and type I endometrial cancer in a Japanese population.
|
19379464 |
2009 |
|
Endometrial Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The homozygous variants of wild p53 codon 72 and mutant MDM2 promoter 309 may cooperatively increase the risk of endometrial cancer in a Japanese population.
|
19874399 |
2009 |
|
Endometrial Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The combination of the MDM2 SNP309 and the three TP53 polymorphisms appear to be related to a higher grade of endometrial cancer.
|
19193430 |
2009 |
|
Endometrial Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Women carrying two copies of the MDM2 SNP309 variant may be at greater risk of endometrial cancer.
|
18398041 |
2008 |
|
Endometrial Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The MDM2 SNP309 homozygous G/G genotype may be a genetic variant that influences sporadic endometrial cancer susceptibility.
|
17123590 |
2007 |