MDM4, MDM4 regulator of p53, 4194

N. diseases: 265; N. variants: 9
Disease: Squamous cell carcinoma of oropharynx ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0280313
Disease: Squamous cell carcinoma of oropharynx
Squamous cell carcinoma of oropharynx 		0.030 GeneticVariation disease BEFREE We concluded that MDM4 rs4245739 polymorphism is significantly associated with tumor HPV status and survival of SCCOP, especially in HPV16-positive SCCOP patients treated with definitive radiotherapy; nevertheless, prospective larger studies are warranted. 31513313 2019
CUI: C0280313
Disease: Squamous cell carcinoma of oropharynx
Squamous cell carcinoma of oropharynx 		0.030 AlteredExpression disease BEFREE Both HPV and MDM4 play a critical role in inhibition of p53 activity, thus affecting HPV tumor status of SCCOP. 29156829 2017
CUI: C0280313
Disease: Squamous cell carcinoma of oropharynx
Squamous cell carcinoma of oropharynx 		0.030 GeneticVariation disease BEFREE The risk of HPV16-associated SCCOP could be modified by MDM4 polymorphisms. 21823114 2012