MDM4, MDM4 regulator of p53, 4194

N. diseases: 265; N. variants: 9
Disease: Mammary Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.340 AlteredExpression group BEFREE Noteworthy, MDM4 transcript levels are significantly reduced in breast tumors characterized by high mTOR levels. 28270148 2017
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.340 AlteredExpression group BEFREE Lastly, we report that endogenous MDM4 negatively regulates ERα expression and forms a protein complex with ERα in breast cancer cell lines and primary human breast tumor tissue. 26909605 2016
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.340 Biomarker group CTD_human Genome-wide association studies identify four ER negative-specific breast cancer risk loci. 23535733 2013
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.340 GeneticVariation group LHGDN Mutation analysis of the MDM4 gene in German breast cancer patients. 18279506 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.340 AlteredExpression group LHGDN Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity. 15199139 2004