ME1, malic enzyme 1, 4199

N. diseases: 58; N. variants: 2
Disease: Metastatic Carcinoma to the Uterine Cervix ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0278584
Disease: Metastatic Carcinoma to the Uterine Cervix
Metastatic Carcinoma to the Uterine Cervix 		0.010 Biomarker disease BEFREE Met and CA regulated metabolic reprogramming in SiHa tumor cells through different mechanisms: Met suppressed regulatory enzymes Glurtaminase (GLS) and Malic Enzyme 1 (ME1) and enhanced pyruvate oxidation via tricarboxylic acids (TCA) cycle, while CA acted as glycolytic inhibitor. 28576465 2017