ME1, malic enzyme 1, 4199

N. diseases: 58; N. variants: 2
Disease: Uterine Corpus Sarcoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0338113
Disease: Uterine Corpus Sarcoma
Uterine Corpus Sarcoma 		0.030 Biomarker disease BEFREE Cytotoxicity evaluation of the synthesized compounds against certain cancer cell lines revealed a number of novel analogues with exceptional potencies [e.g., Tb111: IC<sub>50</sub> = 40 pM against MES SA (uterine sarcoma) cell line; IC<sub>50</sub> = 6 pM against HEK 293T (human embryonic kidney cancer) cell line; and IC<sub>50</sub> = 1.54 nM against MES SA DX (MES SA with marked multidrug resistance) cell line]. 29381062 2018
CUI: C0338113
Disease: Uterine Corpus Sarcoma
Uterine Corpus Sarcoma 		0.030 Biomarker disease BEFREE PGRMC1 contributes to doxorubicin-induced chemoresistance in MES-SA uterine sarcoma. 25596698 2015
CUI: C0338113
Disease: Uterine Corpus Sarcoma
Uterine Corpus Sarcoma 		0.030 Biomarker disease BEFREE A cell line designated MES-SA has been developed from a uterine sarcoma. 6883344 1983