MECP2, methyl-CpG binding protein 2, 4204

N. diseases: 324; N. variants: 57
Disease: Anxiety Disorders ×
Source: BEFREE ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.340 Biomarker group BEFREE Interestingly, female MeCP2-cKO mice displayed reduced anxiety, while males showed increased anxiety and reduced depression-like behaviors. 29636529 2018
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.340 Biomarker group BEFREE Importin α5 Regulates Anxiety through MeCP2 and Sphingosine Kinase 1. 30540948 2018
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.340 Biomarker group BEFREE As compared to wild-type monkeys, MECP2 transgenic monkeys exhibited a higher frequency of repetitive circular locomotion and increased stress responses, as measured by the threat-related anxiety and defensive test. 26808898 2016
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.340 Biomarker group BEFREE IGF1 levels are also reduced in older, fully symptomatic heterozygous (Mecp2(-/+)) female mice, and short-term treatment with rhIGF1 in these animals improves respiratory patterns, reduces anxiety levels, and increases exploratory behavior. 24958891 2014