Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Several lines of evidence point out the relevance of nucleotide-binding oligomerization domain leucine-rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome as a pivotal player in the pathophysiology of several neurological and psychiatric diseases (i.e., Parkinson's disease (PD), Alzheimer's disease (AD), multiple sclerosis (MS), amyotrophic lateral sclerosis, and major depressive disorder), metabolic disorders (i.e., obesity and type 2 diabetes) and chronic inflammatory diseases (i.e., intestinal inflammation, arthritis, and gout).
|
31200447 |
2019 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TNFRSF1A and MEFV mutations in childhood onset multiple sclerosis.
|
28927886 |
2018 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The NOD-like receptor (NLR) family pyrin domain-containing protein 3 (NLRP3) inflammasome is implicated in the pathogenesis of multiple diseases including neuroinflammation associated with multiple sclerosis (MS).
|
28965161 |
2018 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results indicate that MEFV gene mutations do not affect the neurologic prognosis in patients with MS.
|
24712487 |
2015 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results of this study suggest that MEFV gene mutations are positively associated with predisposition to develop MS.
|
23297013 |
2013 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In contrast to recent smaller studies, we did not find an association between carrying a rare variant in the MEFV gene and the risk to develop MS or disease severity.
|
23325590 |
2013 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Also, pyrin mutations were found about 3.5 times higher in the MS patients than the healthy control group.
|
22406096 |
2012 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Frequencies of the pyrin E148Q and K695R mutations were not statistically different between MS group 2 and controls but they occurred with a surprisingly high frequency in the German population.
|
22337722 |
2012 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Homozygosity for the M694V MEFV mutation may aggravate the phenotype of MS and predispose FMF patients to develop MS.
|
21299735 |
2011 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Concurrent TNFRSF1A R92Q and pyrin E230K mutations in a child with multiple sclerosis.
|
20876156 |
2010 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The mean time to reach EDSS score 3.0 was earlier in the patients with MEFV gene mutation (p=0.02) and the relapse rate was slightly higher among the MS patients carrying MEFV gene mutation (p=0.04).
|
20483145 |
2010 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Common mutations in the familial Mediterranean fever gene associate with rapid progression to disability in non-Ashkenazi Jewish multiple sclerosis patients.
|
12700594 |
2003 |