|
Nephroblastoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
A Children's Oncology Group and TARGET initiative exploring the genetic landscape of Wilms tumor.
|
28825729 |
2017 |
|
Bilateral Wilms Tumor
|
0.300 |
Biomarker
|
disease |
CTD_human |
A Children's Oncology Group and TARGET initiative exploring the genetic landscape of Wilms tumor.
|
28825729 |
2017 |
|
Endometrial Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes.
|
23104009 |
2012 |
|
Endometrial Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes.
|
23104009 |
2012 |
|
Ovarian Serous Adenocarcinoma
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Endometriosis
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
GWAS analysis uncovered multiple pathways that are statistically enriched for genetic association signals, analysis of Stage A disease highlighted a novel variant in MAP3K4, while top pathways significantly associated with all endometriosis and Stage A disease included several mitogen-activated protein kinase (MAPK)-related pathways.
|
28333195 |
2017 |
|
Endometriosis
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide genetic analyses highlight mitogen-activated protein kinase (MAPK) signaling in the pathogenesis of endometriosis.
|
28333195 |
2017 |
|
Rheumatoid Arthritis
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis.
|
22491018 |
2013 |
|
Alcoholic Intoxication, Chronic
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q.
|
21956439 |
2012 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, differential expression of implantation and invasion-related molecules, such as cytochrome b-245 light chain (CYBA), neutrophil cytosol factor 2 (NCF2), Mitogen-activated protein kinase kinase kinase 4 (MAP3K4), matrix metalloproteinase 2 (MMP2), MMP9 and tumour necrosis factor α (TNF-α) might induce EED in both EEDT16 and EEDNC patients, although more severe dysfunction in the implantation and invasion ability of villous tissues was observed in EEDT16 patients.
|
30922443 |
2019 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
APOA1, MAP3K4, and MMP14 genes were differentially expressed (FDR < 0.20) between pRT responders and non-responders in preoperative setting, while MAP3K4 was further validated as RT-specific predictive biomarker of distant metastasis free survival (HR = 2.54, [95%CI:1.42-4.55], p = 0.002) in the postoperative setting.
|
30285791 |
2018 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Downregulation of ERBB3 decreases the proliferation, migration and invasion of cervical cancer cells though the interaction with MTK-1.
|
30127948 |
2018 |
|
Neoplasm Metastasis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Importantly, we demonstrated that the overexpression of miR-148a significantly inhibited CSCC cell proliferation and metastasis via down-regulation of MAP3K9 and MAP3K4 expression.
|
26253263 |
2015 |
|
Neuralgia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The expression levels of MAP3K4 were modulated by the increased miR-183 negatively, which lead to the downregulation of IL-6, IL-1β, and COX-2, and then reduced neuropathic pain progression, respectively.
|
31602666 |
2020 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, MAP3K4 is required for cell migration and extracellular acidification of breast cancer cells in response to HER2/HER3 signaling.
|
31346208 |
2019 |
|
Pancreatic carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings support the notion that selective activation of tumor-suppressive MEKK4-MKK4-p38-p21signaling pathway by triptonide is a new approach for pancreatic cancer therapy, providing a new drug candidate for development of novel anti-cancer therapeutics.
|
31075266 |
2019 |
|
Malignant neoplasm of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings support the notion that selective activation of tumor-suppressive MEKK4-MKK4-p38-p21signaling pathway by triptonide is a new approach for pancreatic cancer therapy, providing a new drug candidate for development of novel anti-cancer therapeutics.
|
31075266 |
2019 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, MAP3K4 is required for cell migration and extracellular acidification of breast cancer cells in response to HER2/HER3 signaling.
|
31346208 |
2019 |
|
Polycystic Ovary Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Western blot analyses confirmed that mitogen-activated protein kinase kinase kinase 4 and phospho-ERK1/2 were decreased in PCOS granulosa cells.
|
26459919 |
2015 |
|
Squamous cell carcinoma of skin
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MAP3K4 and MAP3K9 were negatively associated with the expression of miR-148a in CSCC tissues.
|
26253263 |
2015 |
|
Nodule
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Recent studies have shown that mutations in mitogen-activated protein kinase kinase kinase-4 (Mekk4), an indirect interactor with FlnA, also lead to periventricular nodule formation in mice (Sarkisian et al. in 'MEKK4 signaling regulates filamin expression and neuronal migration'.Neuron, 52, 789-801, 2006).
|
18996916 |
2009 |
|
Disorders of Sex Development
|
0.010 |
AlteredExpression
|
group |
BEFREE |
These data demonstrate that MAP3K4-dependent signalling events are required for normal expression of Sry during testis development, and create a novel entry point into the molecular and cellular mechanisms underlying sex determination in mice and disorders of sexual development in humans.
|
19753101 |
2009 |
|
Periventricular Nodular Heterotopia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although PH have not been observed in Flna-deficient mice generated thus far, the loss of MEKK4, a regulator of Flna, produces striking PH in mice and offers insight into the mechanisms involved in neuronal migration initiation.
|
18201775 |
2008 |
|
Degenerative polyarthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
RT-PCR studies of MAP3K gene expression in RA and osteoarthritis synovial tissue demonstrated mitogen-activated protein kinase/ERK kinase kinase (MEKK) 1, MEKK2, apoptosis-signal regulating kinase-1, TGF-beta activated kinase 1 (TAK1) gene expression while only trace amounts of MEKK3, MEKK4, and MLK3 mRNA were detected.
|
14734742 |
2004 |