Parkinson Disease
|
0.360 |
Biomarker
|
disease |
BEFREE |
These findings collectively support inhibiting ASK1 as a disease modifying therapeutic strategy for Parkinson disease and related α-synucleinopathies.
|
31734439 |
2020 |
Parkinson Disease
|
0.360 |
Biomarker
|
disease |
BEFREE |
These results clearly indicate that LRRK2 acts as an upstream kinase in the ASK1 pathway and plays an important role in the pathogenesis of PD.
|
28888991 |
2017 |
Parkinson Disease
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
In addition to its role as an antioxidant enzyme, PRX2 exhibited anti-apoptotic effects in DA neurons via suppression of apoptosis signal-regulating kinase (ASK1)-dependent activation of the c-Jun N-terminal kinase/c-Jun and p38 pro-death pathways, which are also activated in DA neurons of postmortem PD brains.
|
21209210 |
2011 |
Parkinson Disease
|
0.360 |
Biomarker
|
disease |
BEFREE |
In other contexts, both the NFκB (nuclear factor κB) pathway and the ASK1 (apoptosis signaling kinase 1) pathway have been shown to be regulated by both Grx1 and Trx1, and both pathways have been implicated in cell death signaling in model systems of PD.
|
21815648 |
2011 |
Parkinson Disease
|
0.360 |
Biomarker
|
disease |
CTD_human |
In other contexts, both the NFκB (nuclear factor κB) pathway and the ASK1 (apoptosis signaling kinase 1) pathway have been shown to be regulated by both Grx1 and Trx1, and both pathways have been implicated in cell death signaling in model systems of PD.
|
21815648 |
2011 |
Parkinson Disease
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
Consequently, the peripheral cysteine mutants retained cytoprotective activity, whereas the PD-associated mutant [M26I]DJ-1 failed to suppress ASK1 activity and nuclear export of the death domain-associated protein Daxx and did not promote cytoprotection.
|
19293155 |
2009 |
Parkinson Disease
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
This study clearly shows the route from ROS generation by 6-OHDA to initiation of p38/JNK signalling via activation of ASK1 in the studied PD model.
|
16515547 |
2006 |
Parkinson Disease
|
0.360 |
AlteredExpression
|
disease |
LHGDN |
This study clearly shows the route from ROS generation by 6-OHDA to initiation of p38/JNK signalling via activation of ASK1 in the studied PD model.
|
16515547 |
2006 |
Diabetes Mellitus
|
0.340 |
Biomarker
|
group |
BEFREE |
This ASK1 activation strongly correlated with islet amyloidosis and diabetes progression.
|
29627323 |
2018 |
Diabetes Mellitus
|
0.340 |
GeneticVariation
|
group |
BEFREE |
These findings suggest that ER stress-induced ASK1-p38 activation, which is triggered by the accumulation of Ins(C96Y), plays an important role in the pathogenesis of diabetes.
|
23416061 |
2013 |
Diabetes Mellitus
|
0.340 |
AlteredExpression
|
group |
BEFREE |
Diabetes was associated with higher OM Ask1-mRNA only in the lean group.
|
19351724 |
2009 |
Diabetes Mellitus
|
0.340 |
Biomarker
|
group |
BEFREE |
Thioredoxin and binding proteins (ASK1 and TBP2) appear to control apoptosis or metabolic states such as carbohydrate and lipid metabolism related to diseases such as diabetes and atherosclerosis.
|
17115886 |
2007 |
Diabetes Mellitus
|
0.340 |
Biomarker
|
group |
CTD_human |
Apoptosis signal-regulating kinase 1 mediates cellular senescence induced by high glucose in endothelial cells.
|
16731828 |
2006 |
melanoma
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
Somatic mutations in MAP3K5 attenuate its proapoptotic function in melanoma through increased binding to thioredoxin.
|
24008424 |
2014 |
melanoma
|
0.310 |
Biomarker
|
disease |
CTD_human |
The position of the mutations and the loss of heterozygosity of MAP3K5 and MAP3K9 in 85% and 67% of melanoma samples, respectively, together suggest that the mutations are likely to be inactivating.
|
22197930 |
2011 |
Alloxan Diabetes
|
0.300 |
Biomarker
|
disease |
CTD_human |
14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy.
|
18342293 |
2008 |
Diabetes Mellitus, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy.
|
18342293 |
2008 |
Hepatitis, Toxic
|
0.300 |
Biomarker
|
disease |
CTD_human |
Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation.
|
18700144 |
2008 |
Cardiomyopathies, Primary
|
0.300 |
Biomarker
|
group |
CTD_human |
14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy.
|
18342293 |
2008 |
Myocardial Diseases, Secondary
|
0.300 |
Biomarker
|
group |
CTD_human |
14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy.
|
18342293 |
2008 |
Streptozotocin Diabetes
|
0.300 |
Biomarker
|
disease |
CTD_human |
14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy.
|
18342293 |
2008 |
Drug-Induced Liver Disease
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation.
|
18700144 |
2008 |
Cardiomyopathies
|
0.300 |
Biomarker
|
group |
CTD_human |
14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy.
|
18342293 |
2008 |
Hepatitis, Drug-Induced
|
0.300 |
Biomarker
|
disease |
CTD_human |
Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation.
|
18700144 |
2008 |
Drug-Induced Acute Liver Injury
|
0.300 |
Biomarker
|
disease |
CTD_human |
Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation.
|
18700144 |
2008 |