|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Murine B16BL6 tumor are highly pigmented with mostly eumelanin (98.1% of eumelanin) while human SK-MEL-3 tumor contain about 30% pheomelanin.
|
30897406 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Oral administration of JTC801 inhibited growth of xenograft tumors (from PANC1, MiaPaCa2, SK-MEL-28, PC-3, 786-0, SF-295, HCT116, OV-CAR3, and HuH7 cells), orthotropic tumors (from KPC cells), lung metastases (from KPC cells) of mice, and slowed growth of tumors in KCH mice.
|
29248440 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Neuroblastoma RAS viral oncogene homolog was mutated in 12.2% and 26.9% of the tumors in the KMC and TCGA-MEL cohort, respectively.
|
26854490 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The combination of TriMixDC-MEL and ipilimumab is tolerable and results in an encouraging rate of highly durable tumor responses in patients with pretreated advanced melanoma.
|
26926680 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In athymic nude mice subcutaneously implanted with melanoma cells (A375 and SK-MEL-28), we found that combination therapy resulted in greater reduction of tumor growth when compared to individual agents.
|
26299806 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, CH5126766/RO5126766 suppressed the tumor growth in SK-MEL-2 xenograft model.
|
25422890 |
2014 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
One of the MEL.A antigens was shown to result from a point mutation in the tumor.
|
10582700 |
1999 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
SK-MEL-2 cells transfected with sense VEGF (V+) expressed large amounts of mouse and human VEGF protein; V+ cells formed well-vascularized, rapidly growing tumors with minimal tumor necrosis.
|
9751633 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Human melanoma SK-MEL-2 cells best fit these criteria and formed small, poorly vascularized tumors in immunodeficient mice.
|
8548760 |
1996 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Several tumor antigens are recognized by autologous cytolytic T lymphocytes (CTL) on human melanoma MZ2-MEL.
|
7895173 |
1995 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A similar growth-inhibitory effect of AdCMV.p53 was observed with SK-MEL-24 tumors.
|
7591284 |
1995 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, overall production of TNF was > 30-fold lower, compared with a transduced and highly selected tumor cell line control (MEL-TNF).
|
8473752 |
1993 |