|
Male infertility
|
0.030 |
GeneticVariation
|
phenotype |
BEFREE |
Analysis of three maternally imprinted genes (LIT1, SNRPN, MEST), two paternally imprinted genes (MEG3, H19), two repetitive elements (ALU, LINE1), one spermatogenesis-specific gene (VASA) and one gene associated with male infertility (MTHFR) in semen samples demonstrated no alteration in methylation pattern regardless of duration of cryopreservation.
|
22692281 |
2012 |
|
Male infertility
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
We conclude that idiopathic male infertility is strongly associated with imprinting defects at IGF2/H19 ICR1 and MEST, with aberrant MEST methylation being a strong indicator for sperm quality.
|
19878521 |
2010 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In this study, we show monoallelic PEG1 expression in normal breast tissue, indicating the presence of a functional imprint, and more importantly, we demonstrate loss of imprinting (LOI) in all of seven informative invasive breast carcinomas.
|
10554015 |
1999 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
Also, MEST induces metastatic potential of breast cancer through induction of the EMT-TFs-mediated EMT program.
|
30903102 |
2019 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
ZFP57-MEST and the Wnt/β-catenin pathway axis are involved in breast tumorigenesis, which may represent a potential diagnostic biomarker, and provide a new insight into a novel therapeutic strategy for breast cancer patients.
|
30787268 |
2019 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
ZFP57-MEST and the Wnt/β-catenin pathway axis are involved in breast tumorigenesis, which may represent a potential diagnostic biomarker, and provide a new insight into a novel therapeutic strategy for breast cancer patients.
|
30787268 |
2019 |
|
IGA Glomerulonephritis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Since the Oxford Classification of IgA nephropathy (IgAN) was published in 2009, MEST scores have been increasingly used in clinical practice.
|
28341274 |
2017 |
|
IGA Glomerulonephritis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, T scores in MEST classification combined with proteinuria at biopsy could be one of the important early predictors for the renal survial outcomes in patients with IgAN.
|
28439112 |
2017 |
|
Endocapillary hypercellularity
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Renal biopsies were scored for the presence of mesangial hypercellularity (M1), endocapillary hypercellularity (E1), segmental glomerulosclerosis (S1), tubular atrophy/interstitial fibrosis (T1-2) (MEST score) and crescents (C1).
|
27557557 |
2017 |
|
Endocapillary hypercellularity
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Endocapillary hypercellularity and crescents are associated with lower renal survival and more rapid loss of renal function in patients not receiving immunosuppression, whereas crescents in at least 25% of glomeruli predict lower renal survival irrespective of treatment; a C score has been added to the MEST scores in the 2016 revision of the classification.
|
28221174 |
2017 |
|
Benign mixed epithelial and stromal tumor of kidney
|
0.020 |
Biomarker
|
disease |
BEFREE |
A subset of patients with maternal hypomethylation at PLAGL1 have hypomethylation at additional imprinted loci throughout the genome, including GRB10, ZIM2 (PEG3), MEST (PEG1), KCNQ1OT1 and NESPAS (GNAS-AS1).
|
27075368 |
2016 |
|
Oligospermia
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
MEST DNA methylation was significantly associated with oligozoospermia, decreased bi-testicular volume and increased FSH levels.
|
23970452 |
2013 |
|
Benign mixed epithelial and stromal tumor of kidney
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our results indicate that paternal methylation aberrations at imprinting control regions of DLK1-GTL2, MEST (PEG1), and ZAC (PLAGL1) and global methylation levels are not associated with idiopathic RSM and may not be good epigenetic markers (unlike the H-19 imprinting control region) for diagnosis of idiopathic RSM.
|
23415968 |
2013 |
|
Carcinogenesis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Thus, these data demonstrated that tumorigenesis of leiomyoma is associated with overexpression of isoform 1 of PEG1/MEST gene, but not with loss of imprinting of the gene.
|
20339302 |
2010 |
|
Oligospermia
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
The frequency of patients with MEST hypermethylation was highest in the severe oligozoospermia group (2/5 patients), whereas H19 hypomethylation was more frequent in the moderate oligozoospermia (2/5 patients).
|
18178607 |
2008 |
|
Invasive carcinoma of breast
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Promoter switch: a novel mechanism causing biallelic PEG1/MEST expression in invasive breast cancer.
|
12023987 |
2002 |
|
Invasive carcinoma of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
This raises the possibility that aberrant imprinting of PEG1 may be involved in the progression from hyperplasia to invasive breast cancer.
|
10554015 |
1999 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
The loss of imprinting of MEST has been linked to certain types of cancer by promoter switching.
|
30903102 |
2019 |
|
Hypertensive disease
|
0.010 |
Biomarker
|
group |
BEFREE |
We aimed to synthesize epigenomic findings in HTN namely (a) angiotensin-converting enzyme 2 (ACE II) gene, (b) Toll-like receptor 2 (TLR2) gene, (c) interferon γ (IFN-γ) gene, and (d) Capping Actin Protein, Gelosin-Like (<i>CAPG</i>) <i>gene</i>, adducin 1(ADD1) gene, (e) Tissue inhibitor of metalloproteinase 3 (<i>TIMP3</i>), (f) mesoderm specific transcript (MEST) loci, (g) sodium channel epithelial 1 alpha subunit 2 (SCNN1B), (h) glucokinase (CKG) gene (i) angiotensin II receptor, type1 (AGTR1), and DNA methylation (mDNA).
|
31805646 |
2019 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These observations suggest that MEST is a promising target for intervention to prevent tumor metastasis.
|
30903102 |
2019 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
The loss of imprinting of MEST has been linked to certain types of cancer by promoter switching.
|
30903102 |
2019 |
|
Malignant transformation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
MEST of the kidney are a benign group of tumors with very rare incidence of malignant transformation.
|
31495981 |
2019 |
|
Pediatric Obesity
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In total, 26 probes were associated (<i>p</i> < 0.05) with changes in BMI z-score overall, including probes within Mesoderm Specific Transcript <i>(MEST)</i> and Histone Deacetylase 4 (<i>HDAC4</i>), which have previously been associated with childhood obesity and adipogenesis.
|
31216936 |
2019 |
|
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
These observations suggest that MEST is a promising target for intervention to prevent tumor metastasis.
|
30903102 |
2019 |
|
Kidney Failure, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, in patients with nephrotic-range proteinuria, patients in either the C1 or C2 group had a higher rate of the primary outcome, ESRD (HR = 2.54, 95% CI 1.14-5.66) after adjusting for age, gender, eGFR, MAP, MEST scores, and immunosuppressive treatment.
|
29724226 |
2018 |