DisGeNET - a database of gene-disease associations

MET, MET proto-oncogene, receptor tyrosine kinase, 4233

N. diseases: 90; N. variants: 28

Disease: Malignant neoplasm of stomach ×

Source: CURATED ×

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Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Disease

Score _gda

Association Type

Type

Original DB

Sentence supporting the association

PMID

PMID Year

CUI:	C0024623
Disease:	Malignant neoplasm of stomach

Malignant neoplasm of stomach

0.700

Biomarker

disease

CTD_human

Crizotinib thus shows a marked antitumor action both in vitro and in vivo specifically in gastric cancer cells positive for MET amplification.

22729845

2012

CUI:	C0024623
Disease:	Malignant neoplasm of stomach

Malignant neoplasm of stomach

0.700

Biomarker

disease

CTD_human

MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib.

22042947

2011

CUI:	C0024623
Disease:	Malignant neoplasm of stomach

Malignant neoplasm of stomach

0.700

GeneticVariation

disease

UNIPROT

CUI:	C0024623
Disease:	Malignant neoplasm of stomach

Malignant neoplasm of stomach

0.700

GenomicAlterations

disease

CGI