Disease: Neuroblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.340 AlteredExpression disease BEFREE The neuroblastoma SK-N-SH cells with HGF overexpression which activates MET signalling are sensitive to MET inhibitors. 31137515 2019
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.340 GeneticVariation disease BEFREE Accordingly, the combination of the ALK/MET inhibitor crizotinib and selective HDAC8 inhibitors (3-6 µM PCI-34051 or 10 µM 20a) efficiently killed neuroblastoma cell lines carrying wildtype ALK (SK-N-BE(2)-C, IMR5/75), amplified ALK (NB-1), and those carrying the activating ALK F1174L mutation (Kelly), and, in cells carrying the activating R1275Q mutation (LAN-5), combination treatment decreased viable cell count. 29515255 2018
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.340 Biomarker disease BEFREE Activation of the HGF-mediated MET pathway is involved in escape to selective VEGFR inhibition in neuroblastoma suggesting combined inhibition of MET and VEGFR signaling to reduce secondary resistance and enhanced invasiveness. 27922668 2017
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.340 Biomarker disease BEFREE In the metastatic subpopulations, a gene signature was defined (MET-75) that predicted survival of neuroblastoma patients with metastatic disease. 27899382 2017
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.340 Biomarker disease CTD_human The neurotrophin receptor TrkB cooperates with c-Met in enhancing neuroblastoma invasiveness. 16051641 2005