|
Autism Spectrum Disorders
|
0.300 |
Biomarker
|
disease |
BEFREE |
Here, we report that disrupted signaling mediated MET receptor tyrosine kinase (RTK), an established risk factor for autism spectrum disorders, in the developing hippocampus glutamatergic circuit leads to profound deficits in neural development, synaptic transmission, and plasticity.
|
30304576 |
2019 |
|
Autism Spectrum Disorders
|
0.300 |
Biomarker
|
disease |
BEFREE |
MET, the gene encoding the tyrosine kinase receptor for hepatocyte growth factor, is a susceptibility gene for autism spectrum disorder (ASD).
|
30799683 |
2019 |
|
Autism Spectrum Disorders
|
0.300 |
Biomarker
|
disease |
BEFREE |
Met gene-altered mice serve as useful models for mechanistic studies of ASD.
|
29484150 |
2018 |
|
Autism Spectrum Disorders
|
0.300 |
Biomarker
|
disease |
BEFREE |
MET mediates its specific biological effects through different intracellular signaling pathways and has a complex protein interactome that is enriched in autism spectrum disorder and other NDD candidates.
|
27837921 |
2017 |
|
Autism Spectrum Disorders
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The human MET gene imparts a replicated risk for autism spectrum disorder (ASD), and is implicated in the structural and functional integrity of brain.
|
26728565 |
2016 |
|
Autism Spectrum Disorders
|
0.300 |
Biomarker
|
disease |
BEFREE |
Incomplete penetrance in this family was consistent with MET as a partial susceptibility gene for ASD.
|
24909855 |
2014 |
|
Autism Spectrum Disorders
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Autism spectrum disorder: interaction of air pollution with the MET receptor tyrosine kinase gene.
|
24240654 |
2014 |
|
Autism Spectrum Disorders
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
MeCP2 binds to a region of the MET promoter containing the ASD-risk SNV, and displays rs1858830 genotype-specific binding in human neural progenitor cells derived from the olfactory neuroepithelium.
|
24150225 |
2013 |
|
Autism Spectrum Disorders
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that genetic differences in the MET gene may influence the development of cortical systems implicated in the neurobiology of ASD.
|
23097380 |
2012 |
|
Autism Spectrum Disorders
|
0.300 |
Biomarker
|
disease |
BEFREE |
With three converging lines of evidence, we show that a common, functional ASD risk variant in the Met Receptor Tyrosine Kinase (MET) gene is a potent modulator of key social brain circuitry in children and adolescents with and without ASD.
|
22958829 |
2012 |
|
Autism Spectrum Disorders
|
0.300 |
Biomarker
|
disease |
BEFREE |
The expression of MET in restricted human neocortical regions, and its regulation in part by FOXP2, is consistent with genetic evidence for MET contributing to ASD risk.
|
21832174 |
2011 |
|
Autism Spectrum Disorders
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We previously identified two ASD risk genes encoding the receptor tyrosine kinase MET and the urokinase plasminogen activator receptor (PLAUR), which is thought to modulate availability of the MET ligand.
|
21328570 |
2011 |
|
Autism Spectrum Disorders
|
0.300 |
Biomarker
|
disease |
BEFREE |
These results indicate genetic distinction among mothers who produce ASD-associated antibodies to fetal brain proteins, and suggest a potential mechanism for how a genetically determined decrease in MET protein production may lead to a reduction in immune regulation.
|
22833194 |
2011 |
|
Autism Spectrum Disorders
|
0.300 |
Biomarker
|
disease |
BEFREE |
Association of MET with social and communication phenotypes in individuals with autism spectrum disorder.
|
19548256 |
2010 |
|
Autism Spectrum Disorders
|
0.300 |
Biomarker
|
disease |
BEFREE |
These functions may underlie the correlation between altered MET regulation and autism spectrum disorders.
|
19732764 |
2009 |
|
Autism Spectrum Disorders
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Stratification by the presence of gastrointestinal conditions revealed that the MET C allele was associated with both autism spectrum disorder and gastrointestinal conditions in 118 families containing at least 1 child with co-occurring autism spectrum disorder and gastrointestinal conditions.
|
19255034 |
2009 |
|
Autism Spectrum Disorders
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Replicating our initial findings, family-based association test (FBAT) analyses demonstrated that the MET promoter variant rs1858830 C allele was associated with ASD in 101 new families (P=0.033).
|
19360663 |
2008 |
|
Autism Spectrum Disorders
|
0.300 |
Biomarker
|
disease |
BEFREE |
Analyses of coexpression of MET and HGF demonstrated a positive correlation in control subjects that was disrupted in ASD cases.
|
17696172 |
2007 |
|
Autism Spectrum Disorders
|
0.300 |
Biomarker
|
disease |
MGD |
|
|
|